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Strychnine
Strychnine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, glycine receptor subunit alpha-1, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M3, neuronal acetylcholine receptor subunit alpha-9, glycine receptor subunit alpha-2, neuronal acetylcholine receptor subunit alpha-10, glycine receptor subunit alpha-3, and muscarinic acetylcholine receptor M1.
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSTRYCHNINE
INN—
Description
Strychnine is a monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position. It has a role as an avicide, a glycine receptor antagonist, a cholinergic antagonist, a rodenticide and a neurotransmitter agent. It is a monoterpenoid indole alkaloid and an organic heteroheptacyclic compound. It is a conjugate base of a strychnine(1+). It derives from a hydride of a strychnidine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1C[C@@H]2OCC=C3CN4CC[C@]56c7ccccc7N1[C@H]5[C@H]2[C@H]3C[C@H]46
Identifiers
PDB5OBG
CAS-ID57-24-9
RxCUI66422
ChEMBL IDCHEMBL227934
ChEBI ID28973
PubChem CID441071
DrugBankDB15954
UNII ID—
Target
Agency Approved
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Alternate
CHRM2
CHRM2
CHRM4
CHRM4
GLRA1
GLRA1
CHRM5
CHRM5
CHRM3
CHRM3
CHRNA9
CHRNA9
GLRA2
GLRA2
CHRNA10
CHRNA10
GLRA3
GLRA3
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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21,783 adverse events reported
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