Suxamethonium
Suxamethonium is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against acetylcholine receptor subunit alpha.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | 1 | 1 | 2 | 2 | 6 | ||
| Depression | D003863 | F33.9 | — | — | — | 1 | 2 | 3 | |
| Cesarean section | D002585 | — | — | — | 2 | — | 2 | ||
| Anesthesia | D000758 | — | — | — | 2 | — | 2 | ||
| Rapid sequence induction and intubation | D000079603 | — | — | 1 | 1 | — | 2 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 1 | — | 1 |
| Intratracheal intubation | D007442 | — | — | — | 1 | — | 1 | ||
| Postoperative complications | D011183 | — | — | — | 1 | — | 1 | ||
| Intubation | D007440 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| General anesthesia | D000768 | — | — | 1 | — | — | 1 | ||
| Myalgia | D063806 | HP_0003326 | M79.1 | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | — | 1 |
| Shock | D012769 | R57.1 | — | — | 1 | — | — | 1 | |
| Wounds and injuries | D014947 | T14.8 | — | — | 1 | — | — | 1 | |
| Coma | D003128 | HP_0001259 | R40.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bradycardia | D001919 | HP_0001662 | R00.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Patient satisfaction | D017060 | — | — | — | — | 2 | 2 | ||
| Pharyngitis | D010612 | R07.0 | — | — | — | — | 1 | 1 | |
| Fasciculation | D005207 | R25.3 | — | — | — | — | 1 | 1 | |
| Adrenal insufficiency | D000309 | — | — | — | — | 1 | 1 | ||
| Pulmonary atelectasis | D001261 | J98.1 | — | — | — | — | 1 | 1 | |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Mania | D000087122 | F30 | — | — | — | — | 1 | 1 | |
| Hallucinations | D006212 | HP_0000738 | F06.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SUXAMETHONIUM |
| INN | suxamethonium chloride |
| Description | Succinylcholine is a quaternary ammonium ion that is the bis-choline ester of succinic acid. It has a role as a neuromuscular agent, a muscle relaxant and a drug allergen. It is a quaternary ammonium ion and a succinate ester. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives; quaternary ammonium derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C |
Target
Agency Approved
CHRNA1
CHRNA1
Organism
Homo sapiens
Gene name
CHRNA1
Gene synonyms
ACHRA, CHNRA
NCBI Gene ID
Protein name
acetylcholine receptor subunit alpha
Protein synonyms
acetylcholine receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic alpha 1, cholinergic receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), muscle nicotinic acetylcholine receptor, nicotinic acetylcholine receptor alpha subunit, nicotinic cholinergic receptor alpha 1
Uniprot ID
Mouse ortholog
Chrna1 (11435)
acetylcholine receptor subunit alpha (P04756)
Alternate
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Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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29,825 adverse events reported
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