Sulfadoxine
Fansidar (sulfadoxine) is a small molecule pharmaceutical. Sulfadoxine was first approved as Fansidar on 1982-01-01. It is used to treat falciparum malaria and pneumocystis pneumonia in the USA. It is known to target hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pyrimethamine
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Sulfadoxine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FANSIDAR | Roche | N-018557 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| falciparum malaria | EFO_0007444 | D016778 | B50 |
| pneumocystis pneumonia | EFO_0007448 | D011020 | B59 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
45 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic encephalopathy | D006501 | K72.91 | — | 1 | 2 | — | — | 3 | |
| Covid-19 | D000086382 | U07.1 | 1 | 3 | 1 | — | — | 3 | |
| Chorioretinitis | D002825 | HP_0012424 | H30 | — | — | 1 | — | — | 1 |
| Congenital toxoplasmosis | D014125 | EFO_0007220 | P37.1 | — | — | 1 | — | — | 1 |
| Tibial fractures | D013978 | EFO_0003944 | S82.20 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Head and neck neoplasms | D006258 | — | 1 | — | — | 1 | 2 | ||
| Insulin resistance | D007333 | EFO_0002614 | — | 1 | — | — | — | 1 | |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | 1 | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Cerebral toxoplasmosis | D016781 | EFO_0007200 | B58.2 | — | 1 | — | — | — | 1 |
| Wound infection | D014946 | 1 | 1 | — | — | — | 1 | ||
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | — | 4 | 4 |
| Anesthesia | D000758 | — | — | — | — | 1 | 1 | ||
| Delayed emergence from anesthesia | D055191 | — | — | — | — | 1 | 1 | ||
| Neuromuscular blockade | D019148 | — | — | — | — | 1 | 1 | ||
| Critical care | D003422 | — | — | — | — | 1 | 1 | ||
| Ingrown nails | D009263 | L60.0 | — | — | — | — | 1 | 1 | |
| Radiodermatitis | D011855 | L58 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SULFADOXINE |
| INN | sulfadoxine |
| Description | Sulfadoxine is a sulfonamide consisting of pyrimidine having methoxy substituents at the 5- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. In combination with the antiprotozoal pyrimethamine (CHEBI:8673) it is used as an antimalarial. It has a role as an antibacterial drug and an antimalarial. It is a sulfonamide and a member of pyrimidines. |
| Classification | Small molecule |
| Drug class | antimicrobials (sulfonamides derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC |
Identifiers
| PDB | — |
| CAS-ID | 2447-57-6 |
| RxCUI | 10173 |
| ChEMBL ID | CHEMBL1539 |
| ChEBI ID | 9329 |
| PubChem CID | 17134 |
| DrugBank | DB01299 |
| UNII ID | 88463U4SM5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
Organism
Plasmodium falciparum 3D7
Gene name
Gene synonyms
NCBI Gene ID
Protein name
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Protein synonyms
Uniprot ID
Mouse ortholog
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—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,477 adverse events reported
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