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Sulfamethoxazole
Bactrim, Gantanol, Septra, Sulfatrim, Urobak (sulfamethoxazole) is a small molecule pharmaceutical. Sulfamethoxazole was first approved as Gantanol on 1982-01-01. It is used to treat bacterial infections, chlamydiaceae infections, chronic bronchitis, enterobacteriaceae infections, and mycoses amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Combinations
Bactrim, Septra, Sulfatrim (generic drugs available since 1986-08-25, discontinued: Azo gantanol, Cotrim, Cotrim d.s, Septra grape, Sulfamethoprim, Sulfatrim-ss, Sulmeprim, Trimeth/sulfa, Uroplus, Uroplus ss)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenazopyridine hydrochloride
+
Sulfamethoxazole
Tradename
Company
Number
Date
Products
AZO GANTANOLRocheN-013294 DISCN1987-09-10
1 products, RLD
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Phenazopyridine hydrochloride
+
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SULFAMETHOXAZOLE AND TRIMETHOPRIM AND PHENAZOPYRIDINE HYDROCHLORIDEAble LaboratoriesN-021105 DISCN2001-06-26
1 products
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Sulfamethoxazole
Tradename
Company
Number
Date
Products
GANTANOLRocheN-012715 DISCN1982-01-01
1 products
GANTANOL-DSRocheN-012715 DISCN1982-01-01
1 products
GANTANOLRocheN-013664 DISCN1982-01-01
1 products
Hide discontinued
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SEPTRAMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SEPTRA DSMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SULFATRIM PEDIATRICPAI PharmaN-018615 RX1983-01-07
1 products
BACTRIMSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD
BACTRIM DSSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD, RS
Show 14 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bactrim bactrim dsNew Drug Application2021-04-29
sulfamethoxazole and trimethoprimANDA2023-06-12
sulfatrimNew Drug Application2023-01-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
chlamydiaceae infectionsEFO_1001288D002694A70
chronic bronchitis—D029481J42
enterobacteriaceae infectionsEFO_1001313D004756—
mycoses—D009181B35-B49
nocardia infectionsEFO_0007397D009617A43
otitis mediaEFO_0004992D010033H66.9
pneumocystis pneumoniaEFO_0007448D011020B59
protozoan infections—D011528B50-B64
toxoplasmosisEFO_0007517D014123B58
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EC: Intermediate-acting sulfonamides
— J01EC01: Sulfamethoxazole
— J01EE: Combinations of sulfonamides and trimethoprim, incl. derivatives
— J01EE01: Sulfamethoxazole and trimethoprim
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
Code
Description
S0039
Injection, sulfamethoxazole and trimethoprim, 10 ml
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSULFAMETHOXAZOLE
INNsulfamethoxazole
Description
Sulfamethoxazole is an isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antibacterial agent, an antiinfective agent, an epitope, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor, an antimicrobial agent, a P450 inhibitor, an EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a sulfonamide, a member of isoxazoles, a substituted aniline and a sulfonamide antibiotic. It is functionally related to a sulfanilamide.
Classification
Small molecule
Drug classantimicrobials (sulfonamides derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
Identifiers
PDB—
CAS-ID723-46-6
RxCUI10180
ChEMBL IDCHEMBL443
ChEBI ID9332
PubChem CID5329
DrugBankDB01015
UNII IDJE42381TNV (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 45,758 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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83 adverse events reported
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