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Sulpiride
Sulpiride is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor. In addition, it is known to target carbonic anhydrase 1, D(4) dopamine receptor, carbonic anhydrase 7, and carbonic anhydrase 12.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AL: Benzamide antipsychotics
— N05AL01: Sulpiride
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——12—3
Psychotic disordersD011618F20.81———1—1
Schizophrenia spectrum and other psychotic disordersD019967———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Hot flashesD019584——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Abdominal painD015746R10.9————11
Abdominal neoplasmsD000008————11
Treatment-resistant depressive disorderD061218————11
Healthy volunteers/patients—————11
Regional blood flowD012039————11
Ocular physiological phenomenaD009799————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSULPIRIDE
INNsulpiride
Description
Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine. It has a role as an antidepressant, an antiemetic, an antipsychotic agent and a dopaminergic antagonist. It is a N-alkylpyrrolidine, a sulfonamide and a member of benzamides.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)ccc1OC
Identifiers
PDB—
CAS-ID15676-16-1
RxCUI—
ChEMBL IDCHEMBL26
ChEBI ID32168
PubChem CID5355
DrugBankDB00391
UNII ID7MNE9M8287 (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
1814
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Q4VBM8
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
CA1
CA1
DRD4
DRD4
CA7
CA7
CA12
CA12
Organism
Homo sapiens
Gene name
CA1
Gene synonyms
NCBI Gene ID
759
Protein name
carbonic anhydrase 1
Protein synonyms
CA-I, CAB, Carbonate dehydratase I, Carbonic anhydrase B, Carbonic anhydrase I, Cyanamide hydratase CA1, epididymis secretory protein Li 11, epididymis secretory sperm binding protein
Uniprot ID
P00915
Mouse ortholog
Car1 (12346)
carbonic anhydrase 1 (Q9DC84)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,833 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,268 adverse events reported
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