Suramin hexasodium
Suramin hexasodium is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 1 | 3 | — | — | — | 4 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 2 |
| Adrenocortical carcinoma | D018268 | 1 | 1 | — | — | — | 2 | ||
| Central nervous system neoplasms | D016543 | — | 2 | — | — | — | 2 | ||
| Renal cell carcinoma | D002292 | 1 | 1 | — | — | — | 1 | ||
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 1 | — | — | — | 1 |
| Autism spectrum disorder | D000067877 | F84.0 | 1 | 1 | — | — | — | 1 | |
| Plasma cell neoplasms | D054219 | — | 1 | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SURAMIN HEXASODIUM |
| INN | suramin sodium |
| Description | Suramin sodium is an organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. It has a role as an antinematodal drug, a trypanocidal drug, an antineoplastic agent, an angiogenesis inhibitor, an apoptosis inhibitor, an EC 2.7.11.13 (protein kinase C) inhibitor, a GABA antagonist, a GABA-gated chloride channel antagonist, a purinergic receptor P2 antagonist and a ryanodine receptor agonist. It contains a suramin(6-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 129-46-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL413376 |
| ChEBI ID | — |
| PubChem CID | 8514 |
| DrugBank | DBSALT000540 |
| UNII ID | 89521262IH (ChemIDplus, GSRS) |
Target
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Safety
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