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Surinabant
Surinabant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cannabinoid receptor 1. In addition, it is known to target cannabinoid receptor 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Smoking cessationD016540EFO_0004319—1———1
ObesityD009765EFO_0001073E66.9—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSURINABANT
INNsurinabant
Description
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-3-pyrazolecarboxamide is a member of pyrazoles and a ring assembly.
Classification
Small molecule
Drug classcannabinol derivatives: CB (e.g., CB, CB2, etc.) cannabinoid receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Br)cc1
Identifiers
PDB—
CAS-ID288104-79-0
RxCUI—
ChEMBL IDCHEMBL189676
ChEBI ID—
PubChem CID9849616
DrugBankDB13070
UNII IDSF8R9VCB0X (ChemIDplus, GSRS)
Target
Agency Approved
CNR1
CNR1
Organism
Homo sapiens
Gene name
CNR1
Gene synonyms
CNR
NCBI Gene ID
1268
Protein name
cannabinoid receptor 1
Protein synonyms
CANN6, cannabinoid receptor 1 (brain), central cannabinoid receptor
Uniprot ID
Q9UNN0
Mouse ortholog
Cnr1 (12801)
cannabinoid receptor 1 (Q5SF33)
Alternate
CNR2
CNR2
Organism
Homo sapiens
Gene name
CNR2
Gene synonyms
CB2A, CB2B
NCBI Gene ID
1269
Protein name
cannabinoid receptor 2
Protein synonyms
cannabinoid receptor 2 (macrophage), CX5
Uniprot ID
Q6NSY0
Mouse ortholog
Cnr2 (12802)
cannabinoid receptor 2 (Q544H5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 61 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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