Taladegib
Taladegib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein smoothened; smoothened homolog.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | 1 | — | — | — | — | 1 | ||
| Colonic neoplasms | D003110 | C18 | 1 | — | — | — | — | 1 | |
| Cholangiocarcinoma | D018281 | C22.1 | 1 | — | — | — | — | 1 | |
| Medulloblastoma | D008527 | 1 | — | — | — | — | 1 | ||
| Rhabdomyosarcoma | D012208 | 1 | — | — | — | — | 1 | ||
| Neoplasm metastasis | D009362 | EFO_0009708 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TALADEGIB |
| INN | taladegib |
| Description | Taladegib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein smoothened; smoothened homolog. |
| Classification | Small molecule |
| Drug class | hedgehog signaling inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(C(=O)c1ccc(F)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1258861-20-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2142592 |
| ChEBI ID | — |
| PubChem CID | 49848070 |
| DrugBank | — |
| UNII ID | QY8BWX1LJ5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SMO
SMO
Organism
Homo sapiens
Gene name
SMO
Gene synonyms
SMOH
NCBI Gene ID
Protein name
protein smoothened; smoothened homolog
Protein synonyms
frizzled family member 11, Protein Gx, seven transmembrane helix receptor, smoothened, frizzled family receptor, smoothened, seven transmembrane spanning receptor
Uniprot ID
Mouse ortholog
Smo (319757)
protein smoothened; smoothened homolog (P56726)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 109 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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