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Talarozole
Talarozole is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cytochrome P450 26A1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L40—2———2
Acne vulgarisD000152EFO_0003894L70—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTALAROZOLE
INNtalarozole
Description
N-{4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine is a member of the class of benzothiazoles that is 2-amino-1,3-benzothiazole in which one of the amino hydrogens is replaced by a 4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl group. It is a member of triazoles, a member of benzothiazoles, an aromatic amine and a secondary amino compound.
Classification
Small molecule
Drug classaromatase inhibitors (imidazole/triazole derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1
Identifiers
PDB—
CAS-ID201410-53-9
RxCUI—
ChEMBL IDCHEMBL459505
ChEBI ID—
PubChem CID9799888
DrugBankDB13083
UNII IDXKD9N5CJ6W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP26A1
CYP26A1
Organism
Homo sapiens
Gene name
CYP26A1
Gene synonyms
CYP26, P450RAI1
NCBI Gene ID
1592
Protein name
cytochrome P450 26A1
Protein synonyms
Cytochrome P450 retinoic acid-inactivating 1, cytochrome P450, family 26, subfamily A, polypeptide 1, cytochrome P450, subfamily XXVIA, polypeptide 1, Cytochrome P450RAI, hP450RAI, P450, retinoic acid-inactivating, 1, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome
Uniprot ID
Q5VXI0
Mouse ortholog
Cyp26a1 (13082)
cytochrome P450 26A1 (O55127)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 52 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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