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Taletrectinib
Taletrectinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target BDNF/NT-3 growth factors receptor, proto-oncogene tyrosine-protein kinase ROS, NT-3 growth factor receptor, and high affinity nerve growth factor receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8031———4
Non-small-cell lung carcinomaD002289—2———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pharmacogenomic testingD0000711851————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTALETRECTINIB
INNtaletrectinib
Description
Taletrectinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target BDNF/NT-3 growth factors receptor, proto-oncogene tyrosine-protein kinase ROS, NT-3 growth factor receptor, and high affinity nerve growth factor receptor.
Classification
Small molecule
Drug classtyrosine kinase inhibitors: tropomyosin receptor kinase (TRK) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](N)COc1ccc(-c2cnc3ccc(N[C@H](C)c4cccc(F)c4)nn23)cc1
Identifiers
PDB—
CAS-ID1505514-27-1
RxCUI—
ChEMBL IDCHEMBL4650989
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDW4141180YD (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NTRK2
NTRK2
ROS1
ROS1
NTRK3
NTRK3
NTRK1
NTRK1
Organism
Homo sapiens
Gene name
NTRK2
Gene synonyms
TRKB
NCBI Gene ID
4915
Protein name
BDNF/NT-3 growth factors receptor
Protein synonyms
BDNF-tropomyosine receptor kinase B, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, Trk-B, TrkB tyrosine kinase, Tropomyosin-related kinase B, tyrosine kinase receptor B
Uniprot ID
Q16620
Mouse ortholog
Ntrk2 (18212)
BDNF/NT-3 growth factors receptor (Q91XJ9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 55 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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