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Talmapimod
Talmapimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase 11 and mitogen-activated protein kinase 14.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.912———3
Multiple myelomaD009101C90.0—2———2
Myelodysplastic syndromesD009190D46—1———1
Hematologic diseasesD006402EFO_0005803D75.9—1———1
Bone marrow diseasesD001855—1———1
Bone marrow neoplasmsD019046—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTALMAPIMOD
INNtalmapimod
Description
Talmapimod is an indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a N-acylpiperazine, a N-alkylpiperazine, an aromatic amide, a member of monofluorobenzenes, a chloroindole, an indolecarboxamide, a dicarboxylic acid diamide and an aromatic ketone.
Classification
Small molecule
Drug classimmunomodulators: mitogen-activated protein (MAP) kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1CN(C(=O)c2cc3c(C(=O)C(=O)N(C)C)cn(C)c3cc2Cl)[C@H](C)CN1Cc1ccc(F)cc1
Identifiers
PDB—
CAS-ID309913-83-5
RxCUI—
ChEMBL IDCHEMBL514201
ChEBI ID90683
PubChem CID—
DrugBank—
UNII IDB1E00KQ6NT (ChemIDplus, GSRS)
Target
Agency Approved
MAPK11
MAPK11
MAPK14
MAPK14
Organism
Homo sapiens
Gene name
MAPK11
Gene synonyms
PRKM11, SAPK2, SAPK2B
NCBI Gene ID
5600
Protein name
mitogen-activated protein kinase 11
Protein synonyms
MAP kinase 11, MAP kinase p38 beta, Mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, p38-2, p38b, SAPK2b, Stress-activated protein kinase 2b, stress-activated protein kinase-2, stress-activated protein kinase-2b
Uniprot ID
Q2XNF2
Mouse ortholog
Mapk11 (19094)
mitogen-activated protein kinase 11 (Q9WUI1)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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