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Talnetant
Talnetant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target neuromedin-K receptor and substance-K receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20—3———3
Irritable bowel syndromeD043183EFO_0000555K58—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTALNETANT
INNtalnetant
Description
Talnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several functions (primarily treatment of irritable bowel syndrome, despite a 2007 study finding no statistically significant improvement in rectal hypersensitivity over placebo). Its use as a potential antipsychotic drug for the treatment of schizophrenia has also been discontinued.
Classification
Small molecule
Drug classtachykinin (neurokinin) receptor antagonists: NK3 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1
Identifiers
PDB—
CAS-ID174636-32-9
RxCUI—
ChEMBL IDCHEMBL10188
ChEBI ID—
PubChem CID133090
DrugBankDB06429
UNII IDCZ3T9T146K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TACR3
TACR3
TACR2
TACR2
Organism
Homo sapiens
Gene name
TACR3
Gene synonyms
NK3R, TAC3R
NCBI Gene ID
6870
Protein name
neuromedin-K receptor
Protein synonyms
Neurokinin B receptor, neurokinin beta receptor, NK-3 receptor, NK-3R, NK3 receptor, Tachykinin receptor 3
Uniprot ID
Q0P510
Mouse ortholog
Tacr3 (21338)
neuromedin-K receptor (Q9JKN0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 63 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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