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Tamoxifen
Soltamox (tamoxifen) is a small molecule pharmaceutical. Tamoxifen was first approved as Nolvadex on 1982-01-01. It is used to treat breast neoplasms, gynecomastia, pancreatic neoplasms, and precocious puberty in the USA. The pharmaceutical is active against estrogen receptor. In addition, it is known to target G-protein coupled estrogen receptor 1, estrogen receptor beta, and liver carboxylesterase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
Trade Name
FDA
EMA
Soltamox (generic drugs available since 2003-02-20, discontinued: Nolvadex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tamoxifen citrate
Tradename
Company
Number
Date
Products
SOLTAMOXMAYNE PHARMA COMMRCLN-021807 RX2005-10-29
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
soltamoxNew Drug Application2021-11-29
tamoxifen citrateANDA2023-03-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
gynecomastiaHP_0000771D006177N62
pancreatic neoplasmsEFO_0003860D010190C25
precocious puberty—D011629E22.8
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L02: Endocrine therapy antineoplastic and immunomodulating agents
— L02B: Hormone antagonists and related agents
— L02BA: Anti-estrogens
— L02BA01: Tamoxifen
HCPCS
Code
Description
S0187
Tamoxifen citrate, oral, 10 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTAMOXIFEN
INNtamoxifen
Description
Tamoxifen is a tertiary amino compound and a stilbenoid. It has a role as an estrogen receptor antagonist, a bone density conservation agent, an estrogen receptor modulator, an estrogen antagonist, an angiogenesis inhibitor, an EC 2.7.11.13 (protein kinase C) inhibitor, an EC 1.2.3.1 (aldehyde oxidase) inhibitor and an antineoplastic agent. It derives from a hydride of a stilbene.
Classification
Small molecule
Drug classSelective estrogen receptor modulator
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Identifiers
PDB1YA4
CAS-ID10540-29-1
RxCUI10324
ChEMBL IDCHEMBL83
ChEBI ID41774
PubChem CID2733526
DrugBankDB00675
UNII ID094ZI81Y45 (ChemIDplus, GSRS)
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
2099
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Q9UIS7
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
GPER1
GPER1
ESR2
ESR2
CES1
CES1
Organism
Homo sapiens
Gene name
GPER1
Gene synonyms
CEPR, CMKRL2, DRY12, GPER, GPR30
NCBI Gene ID
2852
Protein name
G-protein coupled estrogen receptor 1
Protein synonyms
Chemoattractant receptor-like 2, chemokine receptor-like 2, constitutively expressed peptide-like receptor, FEG-1, Flow-induced endothelial G-protein coupled receptor 1, G protein-coupled estrogen receptor 1, G protein-coupled receptor 30, G-protein coupled receptor 30, GPCR-Br, heptahelix receptor, IL8-related receptor DRY12, LYGPR, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor, mER
Uniprot ID
Q99981
Mouse ortholog
Gper1 (76854)
G-protein coupled estrogen receptor 1 (Q9D392)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 86,579 documents
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Safety
Black-box Warning
Black-box warning for: Soltamox, Tamoxifen citrate
Adverse Events
Top Adverse Reactions
Mock data
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1 adverse events reported
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