Tanespimycin
Tanespimycin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against heat shock protein HSP 90-alpha. In addition, it is known to target hepatocyte growth factor receptor.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
52 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | C90.0 | 2 | 1 | 2 | — | — | 4 | |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 17 | 2 | — | — | — | 18 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 5 | 1 | — | — | — | 6 | |
| Large-cell lymphoma anaplastic | D017728 | C84.6 | 4 | 1 | — | — | — | 5 | |
| Hodgkin disease | D006689 | C81 | 3 | 2 | — | — | — | 5 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 4 | — | — | — | 5 |
| Prostatic neoplasms | D011471 | C61 | 2 | 2 | — | — | — | 4 | |
| Leukemia | D007938 | C95 | 3 | 1 | — | — | — | 4 | |
| Melanoma | D008545 | 1 | 3 | — | — | — | 4 | ||
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 2 | — | — | — | 3 |
| Lung neoplasms | D008175 | C34.90 | 2 | 2 | — | — | — | 3 |
Show 12 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 8 | — | — | — | — | 8 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 8 | — | — | — | — | 8 | |
| B-cell lymphoma marginal zone | D018442 | C88.4 | 5 | — | — | — | — | 5 | |
| Follicular lymphoma | D008224 | C82 | 5 | — | — | — | — | 5 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 5 | — | — | — | — | 5 | |
| Myeloid leukemia acute | D015470 | C92.0 | 4 | — | — | — | — | 4 | |
| Adult t-cell leukemia-lymphoma | D015459 | C91.5 | 4 | — | — | — | — | 4 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 4 | — | — | — | — | 4 | |
| Burkitt lymphoma | D002051 | C83.7 | 4 | — | — | — | — | 4 | |
| Large-cell lymphoma immunoblastic | D016400 | 4 | — | — | — | — | 4 |
Show 29 more
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | TANESPIMYCIN |
| INN | tanespimycin |
| Description | Tanespimycin is a 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects. It has a role as an antineoplastic agent, a Hsp90 inhibitor and an apoptosis inducer. It is a secondary amino compound, an ansamycin, a carbamate ester, an organic heterobicyclic compound and a member of 1,4-benzoquinones. It is functionally related to a geldanamycin. |
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O |
Identifiers
| PDB | — |
| CAS-ID | 75747-14-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL109480 |
| ChEBI ID | 64153 |
| PubChem CID | 6505803 |
| DrugBank | DB05134 |
| UNII ID | 4GY0AVT3L4 (ChemIDplus, GSRS) |
Target
Agency Approved
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
HSP90AA1
Gene synonyms
HSP90A, HSPC1, HSPCA
NCBI Gene ID
Protein name
heat shock protein HSP 90-alpha
Protein synonyms
epididymis luminal secretory protein 52, epididymis secretory sperm binding protein Li 65p, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein 90kDa alpha family class A member 1, HSP 86, HSP86, LAP-2, Lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
Uniprot ID
Mouse ortholog
Hsp90aa1 (15519)
heat shock protein HSP 90-alpha (P07901)
Alternate
MET
MET
Organism
Homo sapiens
Gene name
MET
Gene synonyms
NCBI Gene ID
Protein name
hepatocyte growth factor receptor
Protein synonyms
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Uniprot ID
Mouse ortholog
Met (17295)
hepatocyte growth factor receptor (P16056)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 1,327 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
37 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more