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Taselisib
Taselisib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. In addition, it is known to target phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50441——7
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.0—2———2
LymphomaD008223C85.9—2———2
Squamous cell neoplasmsD018307—1——12
Prostatic neoplasmsD011471C61—1———1
Colorectal neoplasmsD015179—1———1
Ovarian neoplasmsD010051EFO_0003893C56—1———1
Pancreatic neoplasmsD010190EFO_0003860C25—1———1
Endometrial neoplasmsD016889EFO_0004230—1———1
Stomach neoplasmsD013274EFO_0003897C16—1———1
Head and neck neoplasmsD006258—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—3————3
Non-small-cell lung carcinomaD0022891————1
Non-hodgkin lymphomaD008228C85.91————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Squamous cell carcinomaD002294————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTASELISIB
INNtaselisib
Description
Taselisib (development code: GDC-0032) is a former cancer drug candidate that was in development by Roche. It is a small molecule phosphoinositide 3-kinase inhibitor targeting the PI3K isoform p110α (PIK3CA).
Classification
Small molecule
Drug classphosphatidylinositol 3-kinase (PI3K) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1
Identifiers
PDB—
CAS-ID1282512-48-4
RxCUI—
ChEMBL IDCHEMBL2387080
ChEBI ID—
PubChem CID51001932
DrugBankDB12108
UNII IDL08J2O299M (ChemIDplus, GSRS)
Target
Agency Approved
PIK3CD
PIK3CD
Organism
Homo sapiens
Gene name
PIK3CD
Gene synonyms
NCBI Gene ID
5293
Protein name
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein synonyms
p110delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20, phosphoinositide-3-kinase C, phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta, PI3-kinase p110 subunit delta, PI3Kdelta, PtdIns-3-kinase subunit p110-delta
Uniprot ID
Q5SR49
Mouse ortholog
Pik3cd (18707)
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Q8CJ28)
Alternate
PIK3CG
PIK3CG
PIK3CA
PIK3CA
PIK3CB
PIK3CB
Organism
Homo sapiens
Gene name
PIK3CG
Gene synonyms
NCBI Gene ID
5294
Protein name
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Protein synonyms
1-phosphatidylinositol 3-kinase, p110gamma, p120-PI3K, phosphatidylinositol 3 kinase gamma, p110 gamma, phosphatidylinositol 3-kinase catalytic 110-kD gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, phosphoinositide-3-kinase gamma catalytic subunit, PI3-kinase subunit gamma, ptdIns-3-kinase subunit gamma, PtdIns-3-kinase subunit p110-gamma, Serine/threonine protein kinase PIK3CG
Uniprot ID
Q9BZC8
Mouse ortholog
Pik3cg (30955)
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Q9JHG7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 667 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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35 adverse events reported
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