Tegaserod
Zelnorm (tegaserod) is a small molecule pharmaceutical. Tegaserod was first approved as Zelnorm on 2002-07-24. It is used to treat constipation and irritable bowel syndrome in the USA. It is known to target 5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine receptor 4.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tegaserod maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZELNORM | Alfasigma | N-021200 DISCN | 2002-07-24 | 2 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| zelnorm | New Drug Application | 2020-06-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| constipation | HP_0002019 | D003248 | K59.0 |
| irritable bowel syndrome | EFO_0000555 | D043183 | K58 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 1 | 6 | 13 | 1 | — | 20 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 2 | 8 | 3 | — | 13 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 6 | 1 | — | 8 |
| Postoperative pain | D010149 | G89.18 | — | 4 | 2 | 1 | 1 | 8 | |
| Neuralgia | D009437 | EFO_0009430 | — | 1 | 1 | 2 | 2 | 6 | |
| Back pain | D001416 | HP_0003418 | M54 | — | 1 | 2 | 2 | — | 5 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 3 | 1 | — | 5 |
| Acute pain | D059787 | R52 | — | 1 | 2 | 1 | 1 | 5 | |
| Visceral pain | D059265 | — | — | — | 1 | — | 1 | ||
| Peripheral nervous system diseases | D010523 | G64 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | HP_0012532 | — | 1 | 5 | — | 1 | 7 | |
| Neoplasms | D009369 | C80 | — | 1 | 4 | — | 1 | 6 | |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 3 | — | — | 4 | |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | — | 4 | — | — | 4 |
| Hallux valgus | D006215 | HP_0001822 | — | — | 4 | — | — | 4 | |
| Bunion | D000071378 | M21.61 | — | 1 | 2 | — | — | 3 | |
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | — | 2 | — | — | 2 |
| Pain measurement | D010147 | — | — | 2 | — | — | 2 | ||
| Nociceptive pain | D059226 | — | — | 1 | — | — | 1 | ||
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postherpetic neuralgia | D051474 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Analgesia | D000698 | — | — | — | — | 2 | 2 | ||
| Cancer pain | D000072716 | G89.3 | — | — | — | — | 1 | 1 | |
| Substance abuse detection | D015813 | — | — | — | — | 1 | 1 | ||
| Procedural pain | D000073818 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TEGASEROD |
| INN | tegaserod |
| Description | Tegaserod is a member of guanidines, a carboxamidine, a member of hydrazines and a member of indoles. It has a role as a serotonergic agonist and a gastrointestinal drug. |
| Classification | Small molecule |
| Drug class | serotonin receptor antagonists and partial agonists |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 145158-71-0 |
| RxCUI | 139778 |
| ChEMBL ID | CHEMBL76370 |
| ChEBI ID | 51043 |
| PubChem CID | 135409453 |
| DrugBank | DB01079 |
| UNII ID | 458VC51857 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HTR2B
HTR2B
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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29,522 adverse events reported
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