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Micardis, Pritor(telmisartan)
Kinzalkomb, Kinzalmono, Micardis, Pritor, PritorPlus, Twynsta (telmisartan) is a small molecule pharmaceutical. Telmisartan was first approved as Micardis on 1998-11-10. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. It has been approved in Europe to treat essential hypertension and hypertension. The pharmaceutical is active against type-1 angiotensin II receptor. In addition, it is known to target peroxisome proliferator-activated receptor gamma.
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COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
Micardis (generic drugs available since 2014-01-08)
Combinations
Micardis (generic drugs available since 2014-01-08, discontinued: Twynsta)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amlodipine besylate
+
Telmisartan
Tradename
Company
Number
Date
Products
TWYNSTABoehringer IngelheimN-022401 DISCN2009-10-16
4 products, RLD
Hide discontinued
Hydrochlorothiazide
+
Telmisartan
Tradename
Company
Number
Date
Products
MICARDIS HCTBoehringer IngelheimN-021162 RX2000-11-17
3 products, RLD
Telmisartan
Tradename
Company
Number
Date
Products
MICARDISBoehringer IngelheimN-020850 RX1998-11-10
3 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
micardis hctNew Drug Application2022-12-19
telmisartanANDA2023-06-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic nephropathiesEFO_0000401D003928—
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09CA07: Telmisartan
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DA07: Telmisartan and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DB04: Telmisartan and amlodipine
HCPCS
No data
Clinical
Clinical Trials
276 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10146543946159
Healthy volunteers/patients—39——1—40
DyslipidemiasD050171HP_00031194—3119
Covid-19D000086382U07.1—541—8
Essential hypertensionD000075222I103113—8
Type 2 diabetes mellitusD003924EFO_0001360E11——3418
Diabetic nephropathiesD003928EFO_0000401——1416
Metabolic syndromeD024821EFO_0000195E88.81——33—6
Coronary artery diseaseD003324I25.1—113—4
Heart failureD006333EFO_0003144I50—11113
Show 16 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperlipidemiasD006949EFO_0003774E78.57—3——10
HypercholesterolemiaD006937HP_0003124——3——3
Cerebral hemorrhageD002543——2—13
Sars-cov-2D000086402—22——2
Cerebral small vessel diseasesD059345——1—12
Vascular dementiaD015140F01——1—12
HypertriglyceridemiaD015228EFO_00042111—1——2
Polycystic kidney diseasesD007690Q61.3——2——2
Severe acute respiratory syndrome-related coronavirusD045473NCBITaxon_227859—11——1
Hemorrhagic strokeD000083302——1——1
Show 4 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2012———3
Alzheimer diseaseD000544EFO_0000249F0312———2
Insulin resistanceD007333EFO_0002614—1——12
Respiratory distress syndromeD012128EFO_1000637J80—1———1
Respiratory insufficiencyD012131HP_0002093J96.9—1———1
NeuralgiaD009437EFO_0009430—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Obstructive sleep apneaD020181EFO_0003918G47.331————1
Therapeutic equivalencyD0138101————1
Autonomic nervous system diseasesD001342EFO_0009532G901————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437HP_0000083N19————11
Peripheral arterial diseaseD058729EFO_0004265————11
NeoplasmsD009369C80————11
Myocardial ischemiaD017202EFO_1001375I20-I25————11
Angina pectorisD000787EFO_0003913I20————11
Inferior wall myocardial infarctionD056989EFO_1000983————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTELMISARTAN
INNtelmisartan
Description
Telmisartan is a member of the class of benzimidazoles used widely in the treatment of hypertension. It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a xenobiotic and an environmental contaminant. It is a member of biphenyls, a member of benzimidazoles and a carboxybiphenyl.
Classification
Small molecule
Drug classangiotensin II receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
Identifiers
PDB3VN2
CAS-ID144701-48-4
RxCUI73494
ChEMBL IDCHEMBL1017
ChEBI ID9434
PubChem CID65999
DrugBankDB00966
UNII IDU5SYW473RQ (ChemIDplus, GSRS)
Target
Agency Approved
AGTR1
AGTR1
Organism
Homo sapiens
Gene name
AGTR1
Gene synonyms
AGTR1A, AGTR1B, AT2R1, AT2R1B
NCBI Gene ID
185
Protein name
type-1 angiotensin II receptor
Protein synonyms
Angiotensin II type-1 receptor, AT1 receptor, AT1AR, AT1BR, type-1B angiotensin II receptor
Uniprot ID
Q8TBK4
Mouse ortholog
Agtr1b (11608)
type-1 angiotensin II receptor B (P29755)
Alternate
PPARG
PPARG
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
5468
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Q96J12
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 9,679 documents
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Safety
Black-box Warning
Black-box warning for: Micardis hct, Telmisartan
Adverse Events
Top Adverse Reactions
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425 adverse events reported
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