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Viread, Genvoya(tenofovir)
Atripla, Biktarvy, Cimduo, Complera, Delstrigo, Descovy, Genvoya, Odefsey, Stribild, Symfi, Symtuza, Truvada, Vemlidy, Viread (tenofovir) is a small molecule pharmaceutical. Tenofovir was first approved as Viread on 2001-10-26. It is used to treat acquired immunodeficiency syndrome, chronic hepatitis b, hepatitis b, and HIV infections in the USA. It has been approved in Europe to treat hepatitis b and HIV infections.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Viread (generic drugs available since 2015-03-18)
Combinations
Atripla, Cimduo, Complera, Delstrigo, Stribild, Symfi, Symfi lo, Truvada (generic drugs available since 2015-03-18, discontinued: Temixys)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
STRIBILDGilead SciencesN-203100 RX2012-08-27
1 products, RLD, RS
Doravirine
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
DELSTRIGOMerck Sharp & DohmeN-210807 RX2018-08-30
1 products, RLD, RS
Efavirenz
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
ATRIPLAGilead SciencesN-021937 RX2006-07-12
1 products, RLD, RS
Efavirenz
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
SYMFI LOMylanN-208255 RX2018-02-05
1 products, RLD, RS
SYMFIMylanN-022142 RX2018-03-22
1 products, RLD, RS
Show 2 discontinued
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
COMPLERAGilead SciencesN-202123 RX2011-08-10
1 products, RLD, RS
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
TRUVADAGilead SciencesN-021752 RX2004-08-02
4 products, RLD, RS
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
CIMDUOMylanN-022141 RX2018-02-28
1 products, RLD, RS
Show 2 discontinued
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
VIREADGilead SciencesN-021356 RX2001-10-26
4 products, RLD, RS
VIREADGilead SciencesN-022577 RX2012-01-18
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
atriplaNew Drug Application2021-12-14
biktarvyNew Drug Application2022-11-30
cimduoNew Drug Application2021-02-15
complera accessExport only2021-03-29
delstrigoNew Drug Application2022-01-27
descovyNew Drug Application2022-01-13
emtricitabine and tenofovir disoproxil fumarateANDA2023-06-15
genvoyaNew Drug Application2022-01-13
odefseyNew Drug Application2021-09-17
stribildNew Drug Application2021-09-16
Show 6 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acquired immunodeficiency syndromeEFO_0000765D000163B20
chronic hepatitis bEFO_0004239D019694B18.1
hepatitis b—D006509—
hiv infectionsEFO_0000764D015658B20
Agency Specific
FDA
EMA
Expiration
Code
DORAVIRINE / LAMIVUDINE / TENOFOVIR DISOPROXIL FUMARATE, DELSTRIGO, MSD MERCK CO
2025-01-27NPP
2023-08-30NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Doravirine / Lamivudine / Tenofovir Disoproxil Fumarate, Delstrigo, Msd Merck Co
106032822036-11-29DP
108427512036-11-29DP
84869752031-10-07DS, DPU-2395, U-2629, U-3307
Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Disoproxil Fumarate, Complera, Gilead Sciences Inc
108571022033-01-14DP
88413102025-12-09DPU-257
71258792025-04-21DS, DPU-257
80805512023-04-11DS, DP
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate, Stribild, Gilead Sciences Inc
100397182032-10-06DP
86332192030-04-30DPU-257
81483742029-09-03DS, DPU-1279
98912392029-09-03DPU-257
76357042026-10-26DS, DPU-257
89811032026-10-26DS, DP
71762202026-08-27DS, DPU-257
85923972024-01-13DPU-248, U-257, U-541, U-750, U-1170
87162642024-01-13DPU-257
94570362024-01-13DPU-257
97441812024-01-13DPU-257
Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate, Atripla, Gilead Sciences
85981852029-04-28DP
90181922026-06-13U-750, U-1170
95454142026-06-13DPU-750, U-1170
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
— J05AF07: Tenofovir disoproxil
— J05AF13: Tenofovir alafenamide
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR03: Tenofovir disoproxil and emtricitabine
— J05AR06: Emtricitabine, tenofovir disoproxil and efavirenz
— J05AR08: Emtricitabine, tenofovir disoproxil and rilpivirine
— J05AR09: Emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat
— J05AR11: Lamivudine, tenofovir disoproxil and efavirenz
— J05AR12: Lamivudine and tenofovir disoproxil
— J05AR17: Emtricitabine and tenofovir alafenamide
— J05AR18: Emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat
— J05AR19: Emtricitabine, tenofovir alafenamide and rilpivirine
— J05AR20: Emtricitabine, tenofovir alafenamide and bictegravir
— J05AR22: Emtricitabine, tenofovir alafenamide, darunavir and cobicistat
— J05AR24: Lamivudine, tenofovir disoproxil and doravirine
— J05AR27: Lamivudine, tenofovir disoproxil and dolutegravir
HCPCS
No data
Clinical
Clinical Trials
776 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B203172808850308
Chronic hepatitis bD019694EFO_0004197B18.11325173928118
HivD006678O98.71811165222117
Hepatitis bD0065096158161356
Healthy volunteers/patients—23——7232
Acquired immunodeficiency syndromeD000163EFO_0000765B202262214
InfectionsD007239EFO_0000544—363—12
Medication adherenceD055118EFO_00063443123110
Hiv-1D015497—234—9
PregnancyD011247EFO_0002950Z33.11322—8
Show 42 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1—35—16
Sars-cov-2D000086402—12——2
Chronic hepatitis dD019701—11——2
LymphomaD008223C85.9111——2
Treatment adherence and complianceD000074822——2——2
Breast feedingD001942——1——1
Coronavirus infectionsD018352EFO_0007224B34.2——1——1
B-cell lymphomaD016393——1——1
Disease progressionD018450——1——1
Hiv seronegativityD018023—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis dD003699EFO_0007304—4———4
Biliary liver cirrhosisD008105K74.3—1——12
Metabolic syndromeD024821EFO_0000195E88.81—1——12
LipodystrophyD008060E88.1—2———2
ParasitemiaD01851211———1
Pulmonary tuberculosisD014397EFO_1000049A15—1———1
Progressive multifocal leukoencephalopathyD007968EFO_0007455A81.2—1———1
Amphetamine-related disordersD019969EFO_0004701F15—1———1
B-cell chronic lymphocytic leukemiaD015451C91.1—1———1
Large b-cell lymphoma diffuseD016403C83.3—1———1
Show 5 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD0043471———12
ContraceptionD0032671———12
Gender dysphoriaD000068116F641————1
TransgenesD0190761————1
Insulin resistanceD007333EFO_00026141————1
Amyotrophic lateral sclerosisD000690EFO_0000253G12.211————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pregnancy rateD018873————22
Risk reduction behaviorD040242————22
Sustained virologic responseD000072230————11
Job syndromeD007589EFO_0003775D82.4————11
InflammationD007249————11
InfertilityD007246EFO_0000545————11
Liver failureD017093HP_0001399K72.9————11
Virus diseasesD014777B34————11
ProteinuriaD011507HP_0000093R80————11
HyperglycemiaD006943HP_0003074R73.9————11
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTENOFOVIR
INNtenofovir
Description
Tenofovir (anhydrous) is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. It has a role as a HIV-1 reverse transcriptase inhibitor, an antiviral drug and a drug metabolite. It is a member of phosphonic acids and a nucleoside analogue. It is a conjugate acid of a tenofovir(1-).
Classification
Small molecule
Drug classantivirals
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O
Identifiers
PDB—
CAS-ID147127-20-6
RxCUI117466
ChEMBL IDCHEMBL483
ChEBI ID63625
PubChem CID464205
DrugBankDB00300
UNII IDW4HFE001U5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Viread - Gilead Sciences
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Biktarvy - Gilead Sciences
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Descovy - Gilead Sciences
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Genvoya - Gilead Sciences
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Stribild - Gilead Sciences
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Atripla - Gilead Sciences
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Complera - Gilead Sciences
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Odefsey - Gilead Sciences
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Vemlidy - Gilead Sciences
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Truvada - Gilead Sciences
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 27,210 documents
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Safety
Black-box Warning
Black-box warning for: Atripla, Biktarvy, Cimduo, Complera access, Delstrigo, Descovy, Emtricitabine and tenofovir disoproxil fumarate, Genvoya, Odefsey, Stribild, Symfi, Symtuza, Temixys, Truvada, Vemlidy, Viread
Adverse Events
Top Adverse Reactions
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80,970 adverse events reported
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