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Tezampanel
Tezampanel is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glutamate receptor 4, glutamate receptor 1, glutamate receptor 2, and glutamate receptor 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTEZAMPANEL
INNtezampanel
Description
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons.
Classification
Small molecule
Drug classionotropic non-NMDA (N-methyl D-aspartate) glutamate receptors [AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) and/or KA (kainite antagonist) receptors]: antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)[C@@H]1C[C@H]2C[C@@H](CCc3nn[nH]n3)CC[C@H]2CN1
Identifiers
PDB—
CAS-ID154652-83-2
RxCUI—
ChEMBL IDCHEMBL14935
ChEBI ID—
PubChem CID127894
DrugBankDB06354
UNII IDGA36S2O9C2 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GRIA4
GRIA4
GRIA1
GRIA1
GRIA2
GRIA2
GRIA3
GRIA3
Organism
Homo sapiens
Gene name
GRIA4
Gene synonyms
GLUR4
NCBI Gene ID
2893
Protein name
glutamate receptor 4
Protein synonyms
AMPA-selective glutamate receptor 4, GluA4, gluR-4, GluR-D, Glutamate receptor ionotropic, AMPA 4, glutamate receptor, ionotrophic, AMPA 4, glutamate receptor, ionotropic, AMPA 4
Uniprot ID
Q86XE8
Mouse ortholog
Gria4 (14802)
glutamate receptor 4 (Q9Z2W8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 70 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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