Brilinta, Brilique(ticagrelor)
Brilinta, Brilique (ticagrelor) is a small molecule pharmaceutical. Ticagrelor was first approved as Brilique on 2010-12-03. It has been approved in Europe to treat acute coronary syndrome and peripheral vascular diseases. The pharmaceutical is active against P2Y purinoceptor 12. In addition, it is known to target equilibrative nucleoside transporter 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Brilinta (generic drugs available since 2019-01-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ticagrelor
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BRILINTA | AstraZeneca | N-022433 RX | 2011-07-20 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| brilinta | New Drug Application | 2023-01-05 |
| ticagrelor | ANDA | 2020-07-21 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TICAGRELOR, BRILINTA, ASTRAZENECA | |||
| 2025-11-09 | PED | ||
| 2025-05-09 | M-283 | ||
| 2024-05-05 | PED | ||
| 2023-11-28 | PED | ||
| 2023-11-05 | I-848 | ||
| 2023-05-28 | I-851 | ||
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
Clinical Trials
372 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | 2 | 6 | 14 | 49 | 19 | 89 | |
| Coronary artery disease | D003324 | I25.1 | 1 | 12 | 15 | 46 | 12 | 81 | |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 8 | 18 | 5 | 31 |
| St elevation myocardial infarction | D000072657 | — | 2 | 8 | 19 | 2 | 31 | ||
| Healthy volunteers/patients | — | 13 | 4 | — | 2 | — | 19 | ||
| Percutaneous coronary intervention | D062645 | — | 1 | 4 | 6 | 6 | 16 | ||
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | 1 | 1 | 10 | — | 12 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | — | 4 | 6 | — | 11 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | 2 | 5 | 1 | 10 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | 1 | 1 | 6 | 2 | 10 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 7 | — | 1 | 8 | ||
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 2 | 2 | 2 | — | — | 6 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | 1 | 5 | — | — | 5 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | 1 | — | — | 1 |
| Bartter syndrome | D001477 | Orphanet_112 | E26.81 | — | — | 1 | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | 1 | — | — | 1 | |
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | — | — | 1 | — | — | 1 |
| Cerebral infarction | D002544 | I63 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carotid stenosis | D016893 | 1 | 1 | — | — | 1 | 3 | ||
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 2 | — | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | 1 | — | — | — | 2 |
| Critical illness | D016638 | — | 1 | — | — | — | 1 | ||
| Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | 3 | — | — | — | — | 3 | ||
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 | ||
| Biological availability | D001682 | 1 | — | — | — | — | 1 | ||
| Acute lung injury | D055371 | EFO_0004610 | 1 | — | — | — | — | 1 | |
| Healthcare-associated pneumonia | D000077299 | 1 | — | — | — | — | 1 | ||
| Gout | D006073 | EFO_0004274 | M10 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-eluting stents | D054855 | — | — | — | — | 2 | 2 | ||
| Coronary occlusion | D054059 | I21 | — | — | — | — | 1 | 1 | |
| Surgical blood loss | D016063 | — | — | — | — | 1 | 1 | ||
| Hemolysis | D006461 | — | — | — | — | 1 | 1 | ||
| Endotoxemia | D019446 | — | — | — | — | 1 | 1 | ||
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Balloon angioplasty | D000800 | — | — | — | — | 1 | 1 | ||
| Dual anti-platelet therapy | D000080903 | — | — | — | — | 1 | 1 | ||
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TICAGRELOR |
| INN | ticagrelor |
| Description | Ticagrelor is a triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for prevention of thromboembolic events in patients with acute coronary syndrome. It has a role as a platelet aggregation inhibitor and a P2Y12 receptor antagonist. It is a member of triazolopyrimidines, an organofluorine compound, an aryl sulfide, a secondary amino compound and a hydroxyether. |
| Classification | Small molecule |
| Drug class | platelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 274693-27-5 |
| RxCUI | 1116632 |
| ChEMBL ID | CHEMBL398435 |
| ChEBI ID | 68558 |
| PubChem CID | 9871419 |
| DrugBank | DB08816 |
| UNII ID | GLH0314RVC (ChemIDplus, GSRS) |
Target
Agency Approved
P2RY12
P2RY12
Organism
Homo sapiens
Gene name
P2RY12
Gene synonyms
HORK3
NCBI Gene ID
Protein name
P2Y purinoceptor 12
Protein synonyms
ADP-glucose receptor, ADPG-R, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, SP1999
Uniprot ID
Mouse ortholog
P2ry12 (70839)
P2Y purinoceptor 12 (Q9CPV9)
Alternate
SLC29A1
SLC29A1
Organism
Homo sapiens
Gene name
SLC29A1
Gene synonyms
ENT1
NCBI Gene ID
Protein name
equilibrative nucleoside transporter 1
Protein synonyms
Equilibrative NBMPR-sensitive nucleoside transporter, equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter, Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter, es nucleoside transporter, Nucleoside transporter, es-type, solute carrier family 29 (equilibrative nucleoside transporter), member 1, solute carrier family 29 (nucleoside transporters), member 1, Solute carrier family 29 member 1
Uniprot ID
Mouse ortholog
Slc29a1 (63959)
equilibrative nucleoside transporter 1 (Q9JIM1)
Variants
Clinical Variant
No data
Financial
Brilinta - AstraZeneca
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Brilinta, Ticagrelor
Adverse Events
Top Adverse Reactions
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32,748 adverse events reported
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