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Tideglusib
Tideglusib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glycogen synthase kinase-3 beta.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myotonic dystrophyD009223G71.11—32——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F0312———2
Autism spectrum disorderD000067877F84.0—1———1
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21—1———1
Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Progressive supranuclear palsyD013494EFO_0002512G23.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTIDEGLUSIB
INNtideglusib
Description
Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, a neuroprotective agent, an anti-inflammatory agent and an apoptosis inducer. It is a member of naphthalenes, a member of benzenes and a thiadiazolidine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
Identifiers
PDB—
CAS-ID865854-05-3
RxCUI—
ChEMBL IDCHEMBL3545157
ChEBI ID—
PubChem CID11313622
DrugBankDB12129
UNII IDQ747Y6TT42 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GSK3B
GSK3B
Organism
Homo sapiens
Gene name
GSK3B
Gene synonyms
NCBI Gene ID
2932
Protein name
glycogen synthase kinase-3 beta
Protein synonyms
GSK-3 beta, Serine/threonine-protein kinase GSK3B
Uniprot ID
Q9UL47
Mouse ortholog
Gsk3b (56637)
glycogen synthase kinase-3 beta (Q9WV60)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 806 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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