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Tiludronic acid
Skelid (tiludronic acid) is a small molecule pharmaceutical. Tiludronic acid was first approved as Skelid on 1997-03-07. It is known to target 72 kDa type IV collagenase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tiludronate disodium
Tradename
Company
Number
Date
Products
SKELIDSanofiN-020707 DISCN1997-03-07
1 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M05: Drugs for treatment of bone diseases
— M05B: Drugs affecting bone structure and mineralization
— M05BA: Bisphosphonate drugs affecting bone structure and mineralization
— M05BA05: Tiludronic acid
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9———1—1
Cerebral infarctionD002544I63———1—1
PharmacokineticsD010599———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Carotid stenosisD016893——1——1
Peripheral arterial diseaseD058729EFO_0004265——1——1
Myocardial infarctionD009203EFO_0000612I21——1——1
Stable anginaD060050I20.8——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTILUDRONIC ACID
INNtiludronic acid
Description
Tiludronic acid is an organochlorine compound.
Classification
Small molecule
Drug classcalcium metabolism regulators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=P(O)(O)C(Sc1ccc(Cl)cc1)P(=O)(O)O
Identifiers
PDB—
CAS-ID89987-06-4
RxCUI11476
ChEMBL IDCHEMBL1350
ChEBI ID9598
PubChem CID60937
DrugBankDB01133
UNII ID6PNS59HP4Y (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MMP2
MMP2
Organism
Homo sapiens
Gene name
MMP2
Gene synonyms
CLG4A
NCBI Gene ID
4313
Protein name
72 kDa type IV collagenase
Protein synonyms
72 kDa gelatinase, collagenase type IV-A, Gelatinase A, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase-2, matrix metalloproteinase-II, MMP-2, neutrophil gelatinase, TBE-1
Uniprot ID
P08253
Mouse ortholog
Mmp2 (17390)
72 kDa type IV collagenase (P33434)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 76 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,555 adverse events reported
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