Oc000459
Oc000459 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin D2 receptor 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 4 | — | — | — | 5 |
| Allergic rhinitis | D065631 | J30.9 | — | 2 | — | — | — | 2 | |
| Common cold | D003139 | EFO_0007214 | J00 | — | 1 | — | — | — | 1 |
| Rhinovirus | D012229 | — | 1 | — | — | — | 1 | ||
| Picornaviridae infections | D010850 | EFO_0007438 | — | 1 | — | — | — | 1 | |
| Eosinophilia | D004802 | HP_0001880 | D72.1 | — | 1 | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | — | — | — | 1 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | OC000459 |
| INN | timapiprant |
| Description | Oc000459 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin D2 receptor 2. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(Cc2ccc3ccccc3n2)c2cc(F)ccc2n1CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 1422181-22-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL560993 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 04XB9TB8OL (ChemIDplus, GSRS) |
Target
Agency Approved
PTGDR2
PTGDR2
Organism
Homo sapiens
Gene name
PTGDR2
Gene synonyms
CRTH2, DL1R, GPR44
NCBI Gene ID
Protein name
prostaglandin D2 receptor 2
Protein synonyms
CD294, chemoattractant receptor homologous molecule expressed on T helper type 2 cells, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, putative G-protein coupled receptor 44
Uniprot ID
Mouse ortholog
Ptgdr2 (14764)
prostaglandin D2 receptor 2 (Q9Z2J6)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 181 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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