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Tocainide
Tonocard (tocainide) is a small molecule pharmaceutical. Tocainide was first approved as Tonocard on 1984-11-09. It is used to treat cardiac arrhythmias and trigeminal neuralgia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tocainide hydrochloride
Tradename
Company
Number
Date
Products
TONOCARDAstraZenecaN-018257 DISCN1984-11-09
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cardiac arrhythmiasEFO_0004269D001145I49.9
trigeminal neuralgiaEFO_1001219D014277G50.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BB: Antiarrhythmics, class ib
— C01BB03: Tocainide
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.5——11—2
ThyroidectomyD013965———1—1
Shoulder painD020069HP_0030834M25.51———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35111——2
Muscle spasticityD009128HP_0001257111——2
StrokeD020521EFO_0000712I63.9——1——1
Spinal cord injuriesD013119EFO_1001919——1——1
Migraine without auraD020326EFO_0005296G43.0——1——1
Migraine with auraD020325EFO_0005295G43.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep initiation and maintenance disordersD007319F51.01—1———1
Chronic painD059350HP_0012532—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
NeoplasmsD009369C801————1
Cerebral palsyD002547G801————1
Traumatic brain injuriesD000070642S061————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43————11
HeadacheD006261HP_0002315R51————11
ArthritisD001168EFO_0005856M05-M14————11
TendinopathyD052256EFO_1001434M77.9————11
SynovitisD013585EFO_0008997M67.5————11
SpasmD013035M62.83————11
RadiculopathyD011843M54.1————11
GoutD006073EFO_0004274M10————11
Postoperative painD010149G89.18————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOCAINIDE
INNtocainide
Description
Tocainide is a monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic. It has a role as a local anaesthetic, an anti-arrhythmia drug and a sodium channel blocker.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(C)c1NC(=O)C(C)N
Identifiers
PDB—
CAS-ID41708-72-9
RxCUI42359
ChEMBL IDCHEMBL1762
ChEBI ID9611
PubChem CID38945
DrugBankDB01056
UNII ID27DXO59SAN (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 406 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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5,737 adverse events reported
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