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Tolazamide
Tolinase (tolazamide) is a small molecule pharmaceutical. Tolazamide was first approved as Tolinase on 1982-01-01. It is used to treat type 2 diabetes mellitus in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tolazamide
Tradename
Company
Number
Date
Products
TOLAZAMIDECosette Pharmaceuticals N-018894 DISCN1984-11-02
3 products
TOLINASEPharmacia & UpjohnN-015500 DISCN1982-01-01
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
tolazamide2006-12-28
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BB: Sulfonylureas for blood glucose lowering
— A10BB05: Tolazamide
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOLAZAMIDE
INNtolazamide
Description
Tolazamide is an N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus. It has a role as a hypoglycemic agent and a potassium channel blocker.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1
Identifiers
PDB—
CAS-ID1156-19-0
RxCUI10633
ChEMBL IDCHEMBL817
ChEBI ID9613
PubChem CID5503
DrugBankDB00839
UNII ID9LT1BRO48Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 365 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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15 adverse events reported
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