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Tolbutamide
Orinase (tolbutamide) is a small molecule pharmaceutical. Tolbutamide was first approved as Orinase on 1982-01-01. It is used to treat type 2 diabetes mellitus in the USA. The pharmaceutical is active against ATP-sensitive inward rectifier potassium channel 11. In addition, it is known to target ATP-sensitive inward rectifier potassium channel 8.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tolbutamide
Tradename
Company
Number
Date
Products
ORINASEPharmacia & UpjohnN-010670 DISCN1982-01-01
2 products
TOLBUTAMIDESandozN-012678 DISCN1982-01-01
1 products
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Tolbutamide sodium
Tradename
Company
Number
Date
Products
ORINASE DIAGNOSTICPharmacia & UpjohnN-012095 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BB: Sulfonylureas for blood glucose lowering
— A10BB03: Tolbutamide
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CA: Diagnostic agents for diabetes testing
— V04CA01: Tolbutamide
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOLBUTAMIDE
INNtolbutamide
Description
Tolbutamide is an N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. It has a role as a hypoglycemic agent, a potassium channel blocker, a human metabolite and an insulin secretagogue.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
Identifiers
PDB—
CAS-ID64-77-7
RxCUI10635
ChEMBL IDCHEMBL782
ChEBI ID27999
PubChem CID5505
DrugBankDB01124
UNII ID982XCM1FOI (ChemIDplus, GSRS)
Target
Agency Approved
KCNJ11
KCNJ11
Organism
Homo sapiens
Gene name
KCNJ11
Gene synonyms
NCBI Gene ID
3767
Protein name
ATP-sensitive inward rectifier potassium channel 11
Protein synonyms
beta-cell inward rectifier subunit, IKATP, Inward rectifier K(+) channel Kir6.2, inwardly rectifing potassium channel subfamily J member 11, inwardly rectifying potassium channel KIR6.2, inwardly-rectifying potassium channel subfamily J member 11, potassium channel inwardly rectifing subfamily J member 11, Potassium channel, inwardly rectifying subfamily J member 11, potassium voltage-gated channel subfamily J member 11
Uniprot ID
Q8IW96
Mouse ortholog
Kcnj11 (16514)
ATP-sensitive inward rectifier potassium channel 11 (Q9QX21)
Alternate
KCNJ8
KCNJ8
Organism
Homo sapiens
Gene name
KCNJ8
Gene synonyms
NCBI Gene ID
3764
Protein name
ATP-sensitive inward rectifier potassium channel 8
Protein synonyms
Inward rectifier K(+) channel Kir6.1, inwardly rectifying potassium channel KIR6.1, Potassium channel, inwardly rectifying subfamily J member 8, potassium voltage-gated channel subfamily J member 8, uKATP-1
Uniprot ID
Q15842
Mouse ortholog
Kcnj8 (16523)
ATP-sensitive inward rectifier potassium channel 8 (P97794)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 6,165 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7 adverse events reported
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