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Tolimidone
Tolimidone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase Lyn.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11—2———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOLIMIDONE
INNtolimidone
Description
Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. The company proceeded to show that MLR-1023 is an allosteric activator of Lyn kinase with an EC50 of 63 nM. As of 2012 Melior was repurposing it for diabetes. In June 2016, the company reported positive results from their Phase 2a clinical study in diabetic subjects
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(Oc2cnc(=O)[nH]c2)c1
Identifiers
PDB—
CAS-ID41964-07-2
RxCUI—
ChEMBL IDCHEMBL8030
ChEBI ID—
PubChem CID39065
DrugBank—
UNII IDMU3JD8E9IS (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
LYN
LYN
Organism
Homo sapiens
Gene name
LYN
Gene synonyms
JTK8
NCBI Gene ID
4067
Protein name
tyrosine-protein kinase Lyn
Protein synonyms
Lck/Yes-related novel protein tyrosine kinase, p53Lyn, p56Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Uniprot ID
P07948
Mouse ortholog
Lyn (17096)
tyrosine-protein kinase Lyn (Q62127)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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