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Tolonium chloride
Tolonium chloride is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Mouth neoplasmsD009062EFO_0003868C06.91—1—13
Precancerous conditionsD011230——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dental cariesD003731EFO_0003819K021————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Periodontal diseasesD010510K05.6————22
Chronic periodontitisD055113EFO_0006343K05.3————11
Alveolar bone lossD016301————11
Oral lichen planusD017676————11
Oral leukoplakiaD007972K13.21————11
Periodontal pocketD010514EFO_1001393————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOLONIUM CHLORIDE
INNtolonium chloride
Description
Tolonium chloride is an organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques. It has a role as a fluorochrome, a histological dye and a diagnostic agent. It contains a tolonium.
Classification
Small molecule
Drug classquaternary ammonium derivatives; quaternary ammonium derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc2nc3ccc(N(C)C)cc3[s+]c2cc1N.[Cl-]
Identifiers
PDB—
CAS-ID92-31-9
RxCUI—
ChEMBL IDCHEMBL1790006
ChEBI ID87647
PubChem CID7083
DrugBank—
UNII ID15XUH0X66N (ChemIDplus, GSRS)
Target
Agency Approved
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Alternate
No data
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 286 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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