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Tolterodine
Detrol (tolterodine) is a small molecule pharmaceutical. Tolterodine was first approved as Detrol on 1998-03-25. It is used to treat urinary bladder diseases and urinary incontinence in the USA. It is known to target muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M5, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Detrol (generic drugs available since 2015-02-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tolterodine tartrate
Tradename
Company
Number
Date
Products
DETROLUpjohnN-020771 RX1998-03-25
2 products, RLD, RS
DETROL LAUpjohnN-021228 RX2000-12-22
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
detrolNew Drug Application2021-09-29
tolterodine tartrateANDA2023-06-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
urinary bladder diseases—D001745N32.9
urinary incontinenceHP_0000020D014549R32
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04B: Urologicals
— G04BD: Drugs for urinary frequency and incontinence
— G04BD07: Tolterodine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOLTERODINE
INNtolterodine
Description
Tolterodine is a tertiary amine. It has a role as a muscarinic antagonist, a muscle relaxant and an antispasmodic drug. It is functionally related to a p-cresol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
Identifiers
PDB—
CAS-ID124937-51-5
RxCUI119565
ChEMBL IDCHEMBL1382
ChEBI ID9622
PubChem CID443879
DrugBankDB01036
UNII IDWHE7A56U7K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM3
CHRM3
CHRM2
CHRM2
CHRM4
CHRM4
CHRM5
CHRM5
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Variants
Clinical Variant
No data
Financial
Detrol - Pfizer
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,116 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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112 adverse events reported
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