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Tomivosertib
Tomivosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against MAP kinase-interacting serine/threonine-protein kinase 2 and MAP kinase-interacting serine/threonine-protein kinase 1. In addition, it is known to target serine/threonine-protein kinase 17A and dual specificity protein kinase CLK4.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8012———2
Colorectal neoplasmsD015179—1———1
Non-small-cell lung carcinomaD002289—1———1
Triple negative breast neoplasmsD064726—1———1
Liver neoplasmsD008113EFO_1001513C22.0—1———1
LymphomaD008223C85.911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOMIVOSERTIB
INNtomivosertib
Description
Tomivosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against MAP kinase-interacting serine/threonine-protein kinase 2 and MAP kinase-interacting serine/threonine-protein kinase 1. In addition, it is known to target serine/threonine-protein kinase 17A and dual specificity protein kinase CLK4.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Identifiers
PDB—
CAS-ID1849590-01-7
RxCUI—
ChEMBL IDCHEMBL4073443
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDU2H19X4WBV (ChemIDplus, GSRS)
Target
Agency Approved
MKNK2
MKNK2
MKNK1
MKNK1
Organism
Homo sapiens
Gene name
MKNK2
Gene synonyms
GPRK7, MNK2
NCBI Gene ID
2872
Protein name
MAP kinase-interacting serine/threonine-protein kinase 2
Protein synonyms
G protein-coupled receptor kinase 7, MAP kinase interacting serine/threonine kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2
Uniprot ID
Q9HBH9
Mouse ortholog
Mknk2 (17347)
MAP kinase-interacting serine/threonine-protein kinase 2 (Q9D893)
Alternate
STK17A
STK17A
CLK4
CLK4
Organism
Homo sapiens
Gene name
STK17A
Gene synonyms
DRAK1
NCBI Gene ID
9263
Protein name
serine/threonine-protein kinase 17A
Protein synonyms
DAP kinase-related apoptosis-inducing protein kinase 1, death-associated protein kinase-related 1, serine/threonine kinase 17a (apoptosis-inducing)
Uniprot ID
Q9UEE5
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 81 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,178 adverse events reported
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