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Topiroxostat
Topiroxostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target xanthine dehydrogenase/oxidase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperuricemiaD033461—1———1
Diabetic nephropathiesD003928EFO_0000401—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOPIROXOSTAT
INNtopiroxostat
Description
Topiroxostat (INN; trade names Topiloric, Uriadec) is a drug for the treatment of gout and hyperuricemia. It was approved for use in Japan in June 2013.
Classification
Small molecule
Drug classenzyme inhibitors: xanthine oxidase/dehydrogenase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N#Cc1cc(-c2n[nH]c(-c3ccncc3)n2)ccn1
Identifiers
PDB—
CAS-ID577778-58-6
RxCUI—
ChEMBL IDCHEMBL1078685
ChEBI ID—
PubChem CID5288320
DrugBankDB01685
UNII ID0J877412JV (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
XDH
XDH
Organism
Homo sapiens
Gene name
XDH
Gene synonyms
XDHA
NCBI Gene ID
7498
Protein name
xanthine dehydrogenase/oxidase
Protein synonyms
xanthine oxidoreductase
Uniprot ID
Q4PJ16
Mouse ortholog
Xdh (22436)
xanthine dehydrogenase/oxidase (Q00519)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 235 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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