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Toreforant
Toreforant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histamine H4 receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.913———4
PsoriasisD011565EFO_0000676L40—1———1
AsthmaD001249EFO_0000270J45—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Hepatic insufficiencyD0485501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOREFORANT
INNtoreforant
Description
Toreforant (JNJ-38518168) is an orally-dosed selective antagonist of the histamine H4 receptor that has been studied for various health conditions. It is the successor of a number of H4-selective compounds developed by Johnson & Johnson. Phase IIa clinical trials completed as recently as November 2018 continue to suggest that toreforant is safe.
Classification
Small molecule
Drug classhistamine H4 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(C)c2nc(-c3cnc(NCCCC4CCN(C)CC4)nc3C)[nH]c2c1
Identifiers
PDB—
CAS-ID952494-46-1
RxCUI—
ChEMBL IDCHEMBL3301609
ChEBI ID—
PubChem CID23650961
DrugBankDB12522
UNII IDU6LA7G393X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HRH4
HRH4
Organism
Homo sapiens
Gene name
HRH4
Gene synonyms
GPCR105
NCBI Gene ID
59340
Protein name
histamine H4 receptor
Protein synonyms
AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144
Uniprot ID
Q9H3N8
Mouse ortholog
Hrh4 (225192)
histamine H4 receptor (Q91ZY2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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