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Tozasertib
Tozasertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against aurora kinase B, aurora kinase A, and aurora kinase C.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C95—1———1
Non-small-cell lung carcinomaD002289—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_00003402————2
NeoplasmsD009369C802————2
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.01————1
Myelodysplastic syndromesD009190D461————1
Precursor t-cell lymphoblastic leukemia-lymphomaD0542181————1
Colorectal neoplasmsD0151791————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOZASERTIB
INNtozasertib
Description
N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide is a N-arylpiperazine.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1
Identifiers
PDB4B8M
CAS-ID639089-54-6
RxCUI—
ChEMBL IDCHEMBL572878
ChEBI ID—
PubChem CID5494449
DrugBank—
UNII ID234335M86K (ChemIDplus, GSRS)
Target
Agency Approved
AURKB
AURKB
AURKA
AURKA
AURKC
AURKC
Organism
Homo sapiens
Gene name
AURKB
Gene synonyms
AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
NCBI Gene ID
9212
Protein name
aurora kinase B
Protein synonyms
AIM-1, ARK-2, Aurora 1, aurora kinase B-Sv1, aurora kinase B-Sv2, Aurora- and IPL1-like midbody-associated protein 1, aurora- and Ipl1-like midbody-associated protein 1 homolog, aurora-1, aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, STK-1
Uniprot ID
Q96GD4
Mouse ortholog
Aurkb (20877)
aurora kinase B (Q8C6C1)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 345 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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