Trafermin
Trafermin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 2 | 2 | — | — | 4 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | 2 | — | — | 2 | |
| Tympanic membrane perforation | D018058 | H72 | — | — | 1 | — | — | 1 | |
| Alveolar bone loss | D016301 | — | — | 1 | — | — | 1 | ||
| Periodontal attachment loss | D017622 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TRAFERMIN |
| INN | trafermin |
| Description | Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in Japan as a topical spray for the treatment of skin ulcers. It is also currently in preregistration for the treatment of periodontitis. As a recombinant form of bFGF, trafermin is a potent agonist of the FGFR1, FGFR2, FGFR3, and FGFR4. The drug has been marketed in Japan since June 2001.
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| Classification | Protein |
| Drug class | growth factors: fibroblast growth factors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 131094-16-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108081 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06244 |
| UNII ID | 333OX80X87 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 119 documents
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Safety
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Adverse Events
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0 adverse events reported
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