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Tranylcypromine
Parnate (tranylcypromine) is a small molecule pharmaceutical. Tranylcypromine was first approved as Parnate on 1985-08-16. It is used to treat depressive disorder and post-traumatic stress disorders in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] B and amine oxidase [flavin-containing] A. In addition, it is known to target lysine-specific histone demethylase 1A and prostacyclin synthase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Parnate (generic drugs available since 2006-06-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tranylcypromine sulfate
Tradename
Company
Number
Date
Products
PARNATEConcordia LaboratoriesN-012342 RX1985-08-16
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
parnateNew Drug Application2021-01-19
tranylcypromine sulfateANDA2023-05-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
post-traumatic stress disordersEFO_0001358D013313F43.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AF: Monoamine oxidase inhibitors, non-selective
— N06AF04: Tranylcypromine
HCPCS
No data
Clinical
Clinical Trials
83 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Overactive urinary bladderD053201EFO_1000781N32.816101614549
Urinary incontinenceD014549HP_0000020R32—118111
Healthy volunteers/patients—2——2—4
Urge urinary incontinenceD053202EFO_0006865N39.41———314
Chronic painD059350HP_0012532———2—2
Prostatic hyperplasiaD011470EFO_0000284N40———2—2
MemoryD008568———1—1
CognitionD003071EFO_0003925———1—1
Ureteral obstructionD014517HP_0006000———1—1
Urinary bladder neck obstructionD001748EFO_1000840N32.0———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lower urinary tract symptomsD059411EFO_0008008—11—12
Low back painD017116HP_0003419M54.5——1——1
PainD010146EFO_0003843R52——1——1
Pelvic organ prolapseD056887EFO_0004710——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuralgiaD009437EFO_000943011———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ProstatitisD011472EFO_0003830N41————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRANYLCYPROMINE
INNtranylcypromine
Description
(1R,2S)-tranylcypromine is a 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. It is a conjugate base of a (1R,2S)-tranylcypromine(1+). It is an enantiomer of a (1S,2R)-tranylcypromine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1
Identifiers
PDB—
CAS-ID155-09-9
RxCUI10734
ChEMBL IDCHEMBL3989843
ChEBI ID—
PubChem CID19493
DrugBankDB00752
UNII ID3E3V44J4Z9 (ChemIDplus, GSRS)
Target
Agency Approved
MAOB
MAOB
MAOA
MAOA
Organism
Homo sapiens
Gene name
MAOB
Gene synonyms
NCBI Gene ID
4129
Protein name
amine oxidase [flavin-containing] B
Protein synonyms
adrenalin oxidase, MAO, brain, MAO, platelet, MAO-B, Monoamine oxidase type B, tyramine oxidase
Uniprot ID
Q7Z6S2
Mouse ortholog
Maob (109731)
amine oxidase [flavin-containing] B (Q8C0B2)
Alternate
KDM1A
KDM1A
PTGIS
PTGIS
Organism
Homo sapiens
Gene name
KDM1A
Gene synonyms
AOF2, KDM1, KIAA0601, LSD1
NCBI Gene ID
23028
Protein name
lysine-specific histone demethylase 1A
Protein synonyms
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A, amine oxidase (flavin containing) domain 2, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, Flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1A, lysine-specific histone demethylase 1
Uniprot ID
O60341
Mouse ortholog
Kdm1a (99982)
lysine-specific histone demethylase 1A (Q8VEA1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,170 documents
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Safety
Black-box Warning
Black-box warning for: Parnate, Tranylcypromine sulfate
Adverse Events
Top Adverse Reactions
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6,967 adverse events reported
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