Triamcinolone acetonide

Aristocort, Kenacort, Kenalog, Myco-triacet, Mycolog-ii, Mytrex, Nasacort, Triesence, Xipere, Zilretta (triamcinolone acetonide) is a small molecule pharmaceutical. Triamcinolone acetonide was first approved as Aristocort on 1982-01-01. It is used to treat adrenal insufficiency, allergic rhinitis perennial, ankylosing spondylitis, atopic dermatitis, and berylliosis amongst others in the USA. It is known to target glucocorticoid receptor.

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BMS

Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
musculoskeletal diseases	D009140
digestive system diseases	D004066
respiratory tract diseases	D012140
otorhinolaryngologic diseases	D010038
nervous system diseases	D009422
eye diseases	D005128
urogenital diseases	D000091642
hemic and lymphatic diseases	D006425
hereditary congenital and neonatal diseases and abnormalities	D009358

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Trade Name

FDA

EMA

Kenalog, Nasacort, Triesence, Xipere, Zilretta (generic drugs available since 1982-01-01, discontinued: Allernaze, Aristocort, Aristocort a, Aristogel, Azmacort, Flutex, Kenacort, Oralone, Triacet, Triacort, Triatex, Trivaris, Trymex)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Triamcinolone

Tradename	Company	Number	Date	Products
ARISTOCORT	Astellas Pharma	N-011161 DISCN	1982-01-01	5 products
KENACORT	Delcor Asset	N-011283 DISCN	1982-01-01	4 products

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Triamcinolone acetonide

Tradename	Company	Number	Date	Products
KENALOG-10	Bristol Myers Squibb	N-012041 RX	1982-01-01	1 products, RLD
KENALOG-80	Bristol Myers Squibb	N-014901 RX	2019-04-12	1 products, RLD, RS
KENALOG-40	Bristol Myers Squibb	N-014901 RX	1982-01-01	1 products, RLD, RS
XIPERE	Bausch Health Companies	N-211950 RX	2021-10-22	1 products, RLD, RS
NASACORT ALLERGY 24 HOUR	Sanofi	N-020468 OTC	2013-10-11	1 products, RLD, RS
TRIESENCE	Novartis	N-022048 RX	2007-11-29	1 products, RLD, RS
ZILRETTA	Pacira BioSciences	N-208845 RX	2017-10-06	1 products, RLD, RS
KENALOG	Sun Pharmaceutical Industries	N-012104 RX	1982-01-01	1 products, RLD, RS

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Triamcinolone diacetate

Tradename	Company	Number	Date	Products
ARISTOCORT	Astellas Pharma	N-011960 DISCN	1982-01-01	1 products
KENACORT	Delcor Asset	N-012515 DISCN	1982-01-01	1 products
ARISTOCORT	Fosun Pharmaceutical	N-011685 DISCN	1982-01-01	1 products
ARISTOCORT	Fosun Pharmaceutical	N-012802 DISCN	1982-01-01	1 products, RLD

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Labels

FDA

EMA

Brand Name	Status	Last Update
allernaze	New Drug Application	2010-11-23
lidolog kit	unapproved drug other	2023-05-15
nasacort allergy 24hr	New Drug Application	2022-04-20
oralone	ANDA	2019-01-14
triamcinolone acetonide	ANDA	2023-06-19
trianex 0.05%	ANDA	2021-05-12
triderm	ANDA	2023-02-13
triesence	New Drug Application	2020-10-02
xipere	New Drug Application	2021-10-25
xuriden	New Drug Application	2019-12-16

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
adrenal insufficiency	—	D000309	—
allergic rhinitis perennial	EFO_1001417	D012221	J30.89
ankylosing spondylitis	EFO_0003898	D013167	M45
atopic dermatitis	EFO_0000274	D003876	L20
berylliosis	EFO_0007168	D001607	J63.2
bronchial spasm	—	D001986	—
dermatitis herpetiformis	—	D003874	L13.0
erythema multiforme	—	D004892	L51
facial dermatoses	—	D005148	—
foot dermatoses	—	D005533	—

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Agency Specific

FDA

EMA

Expiration	Code
TRIAMCINOLONE ACETONIDE, XIPERE, BAUSCH AND LOMB INC
2024-10-22	NP

Patent Expiration

Patent	Expires	Flag	FDA Information
Triamcinolone Acetonide, Xipere, Bausch And Lomb Inc
9937075	2034-05-02	DP
9636332	2033-11-08		U-3234
8636713	2027-05-02		U-3234
Triamcinolone Acetonide, Zilretta, Pacira Pharms Inc
8828440	2031-08-04	DP
9555048	2031-08-04		U-2151
Triamcinolone Acetonide, Triesence, Novartis
8128960	2029-12-17	DP
8211880	2029-03-10		U-1257, U-1258

ATC Codes

A: Alimentary tract and metabolism drugs

— A01: Stomatological preparations

— A01A: Stomatological preparations

— A01AC: Corticosteroids for local oral treatment

— A01AC01: Triamcinolone

C: Cardiovascular system drugs

— C05: Vasoprotectives

— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use

— C05AA: Corticosteroids, topical for treatment of hemorrhoids and anal fissures

— C05AA12: Triamcinolone

D: Dermatologicals

— D07: Corticosteroids, dermatological preparations

— D07A: Corticosteroid dermatological preparations, plain

— D07AB: Corticosteroids, moderately potent (group ii)

— D07AB09: Triamcinolone

— D07B: Corticosteroids, combinations with antiseptics

— D07BB: Corticosteroids, moderately potent, combinations with antiseptics

— D07BB03: Triamcinolone and antiseptics

— D07C: Corticosteroids, combinations with antibiotics

— D07CB: Corticosteroids, moderately potent, combinations with antibiotics

— D07CB01: Triamcinolone and antibiotics

— D07X: Corticosteroids, other combinations

— D07XB: Corticosteroids, moderately potent, other combinations

— D07XB02: Triamcinolone

H: Systemic hormonal preparations, excl. sex hormones and insulins

— H02: Corticosteroids for systemic use

— H02A: Corticosteroids for systemic use, plain

— H02AB: Glucocorticoids, systemic

— H02AB08: Triamcinolone

R: Respiratory system drugs

— R01: Nasal preparations

— R01A: Decongestants and other nasal preparations for topical use

— R01AD: Corticosteroid nasal preparations for topical use

— R01AD11: Triamcinolone

— R03: Drugs for obstructive airway diseases

— R03B: Other drugs for obstructive airway diseases, inhalants in atc

— R03BA: Glucocorticoid inhalants for obstructive airway disease

— R03BA06: Triamcinolone

S: Sensory organ drugs

— S01: Ophthalmologicals

— S01B: Antiinflammatory agents, ophthalmologic

— S01BA: Corticosteroid ophthalmologic antiinflammatory agents, plain

— S01BA05: Triamcinolone

— S02: Otologicals

— S02C: Corticosteroids and antiinfectives in combination, otologic

— S02CA: Corticosteroids and antiinfectives in combination

— S02CA04: Triamcinolone and antiinfectives

HCPCS

Code	Description
J3300	Injection, triamcinolone acetonide, preservative free, 1 mg
J3301	Injection, triamcinolone acetonide, not otherwise specified, 10 mg
J3304	Injection, triamcinolone acetonide, preservative-free, extended-release, microsphere formulation, 1 mg

Clinical

Clinical Trials

590 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Macular edema	D008269			8	11	20	4	10	50
Knee osteoarthritis	D020370	EFO_0004616	M17	3	10	5	12	5	33
Macular degeneration	D008268	EFO_0001365	H35.30	3	4	8	1	3	17
Retinal vein occlusion	D012170	EFO_1001157	H34.81	2	4	5	1	5	16
Alopecia areata	D000506	EFO_0004192	L63	1	3	—	6	4	13
Oral lichen planus	D017676			3	5	1	2	2	13
Keloid	D007627	EFO_0004212	L91.0	1	2	1	3	6	12
Shoulder pain	D020069	HP_0030834	M25.51	—	3	—	3	4	10
Carpal tunnel syndrome	D002349	EFO_0004143	G56.0	—	1	2	1	7	10
Atopic dermatitis	D003876	EFO_0000274	L20	—	3	—	4	2	9

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Bursitis	D002062	EFO_1000941	M71.9	1	1	2	—	8	12
Diabetic retinopathy	D003930	EFO_0003770		5	5	4	—	—	11
Cataract	D002386	EFO_0001059	H26.9	—	2	3	—	4	8
Hip osteoarthritis	D015207	EFO_1000786	M16	—	2	2	—	1	5
Gouty arthritis	D015210			—	1	3	—	—	4
Chronic pancreatitis	D050500	EFO_0000342	K86.1	—	—	1	—	2	3
Vitiligo	D014820	EFO_0004208	L80	—	2	1	—	1	3
Ischemic optic neuropathy	D018917	EFO_1000809	H47.01	1	1	1	—	—	2
Chemotherapy-induced febrile neutropenia	D064146			—	1	1	—	—	2
Liver transplantation	D016031	EFO_0010682		—	—	2	—	—	2

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Alzheimer disease	D000544	EFO_0000249	F03	1	1	—	—	12	13
Cognitive dysfunction	D060825		G31.84	2	2	—	—	6	9
Kidney transplantation	D016030			1	5	—	—	—	5
Liver neoplasms	D008113	EFO_1001513	C22.0	1	4	—	—	—	4
T-cell lymphoma cutaneous	D016410		C84.A	1	1	—	—	1	3
Psoriasis	D011565	EFO_0000676	L40	1	2	—	—	—	3
Transcranial direct current stimulation	D065908			1	1	—	—	2	3
Asthma	D001249	EFO_0000270	J45	—	1	—	—	2	3
Therapeutics	D013812			—	1	—	—	1	2
Melanoma	D008545			—	1	—	—	1	2

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Schizophrenia	D012559	EFO_0000692	F20	1	—	—	—	7	8
Cicatrix	D002921	HP_0100699	L90.5	1	—	—	—	2	3
Neuralgia	D009437	EFO_0009430		1	—	—	—	1	2
Leiomyoma	D007889	HP_0000131	D25	1	—	—	—	—	1
Adenomyosis	D062788	EFO_1001757	N80.0	1	—	—	—	—	1
Humeral fractures	D006810	EFO_0003943	S42.3	1	—	—	—	—	1
Vasoconstriction	D014661			1	—	—	—	—	1
Papilledema	D010211	EFO_1001074	H35.81	1	—	—	—	—	1
Acoustic neuroma	D009464	HP_0009588		1	—	—	—	—	1
Drug interactions	D004347			1	—	—	—	—	1

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—			—	—	—	—	7	7
Memory disorders	D008569			—	—	—	—	4	4
Dementia	D003704		F03	—	—	—	—	4	4
Psychotic disorders	D011618		F20.81	—	—	—	—	3	3
Major depressive disorder	D003865	EFO_0003761	F22	—	—	—	—	3	3
Parkinson disease	D010300	EFO_0002508	G20	—	—	—	—	3	3
Skin diseases	D012871		L00-L99	—	—	—	—	3	3
Hemianopsia	D006423		H53.46	—	—	—	—	2	2
Essential tremor	D020329	EFO_0003108	G25.0	—	—	—	—	2	2
Frontotemporal dementia	D057180		G31.0	—	—	—	—	2	2

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	TRIAMCINOLONE ACETONIDE
INN	triamcinolone
Description	Triamcinolone acetonide is a synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections. It has a role as an anti-inflammatory drug and an anti-allergic agent. It is an 11beta-hydroxy steroid, a 20-oxo steroid, a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a glucocorticoid, a cyclic ketal, a fluorinated steroid and a primary alpha-hydroxy ketone. It is functionally related to a triamcinolone. It derives from a hydride of a pregnane.
Classification	Small molecule
Drug class	steroids (not prednisolone derivatives); topical steroids (acetal derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

Identifiers

PDB	5UFS
CAS-ID	76-25-5
RxCUI	10761
ChEMBL ID	CHEMBL1504
ChEBI ID	71418
PubChem CID	6436
DrugBank	DB00620
UNII ID	1ZK20VI6TY (ChemIDplus, GSRS)

Target

Agency Approved

No data

Alternate

NR3C1

Organism

Homo sapiens

Gene name

NR3C1

Gene synonyms

GRL

NCBI Gene ID

2908

Protein name

glucocorticoid receptor

Protein synonyms

Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Uniprot ID

Q6N0A4

Mouse ortholog

Nr3c1 (14815)

glucocorticoid receptor (Q61629)

Variants

Clinical Variant

No data

Financial

Zilretta - Flexion Therapeutics

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Zilretta - Pacira BioSciences

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Safety

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Adverse Events

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1,202 adverse events reported

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