Triclosan
Colgate Total (triclosan) is a small molecule pharmaceutical. Triclosan was first approved as Colgate total on 1997-07-11. It is used to treat bacterial infections and mycoses in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium fluoride
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Triclosan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLGATE TOTAL | Colgate-Palmolive | N-020231 DISCN | 1997-07-11 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| colgate total sf clean mint | OTC monograph final | 2023-03-17 |
| ecolab | OTC monograph not final | 2023-06-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections and mycoses | — | D001423 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
HCPCS
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Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TRICLOSAN |
| INN | triclosan |
| Description | Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an antibacterial agent, a fungicide, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antimalarial, an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a xenobiotic, a persistent organic pollutant and a drug allergen. It is a member of phenols, an aromatic ether, a dichlorobenzene and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 3380-34-5 |
| RxCUI | 10795 |
| ChEMBL ID | CHEMBL849 |
| ChEBI ID | 164200 |
| PubChem CID | 5564 |
| DrugBank | DB08604 |
| UNII ID | 4NM5039Y5X (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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819 adverse events reported
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