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Trihexyphenidyl
Artane, Tremin (trihexyphenidyl) is a small molecule pharmaceutical. Trihexyphenidyl was first approved as Artane on 1982-01-01. It is used to treat drug-induced abnormalities and parkinson disease in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M1.
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Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trihexyphenidyl hydrochloride
Tradename
Company
Number
Date
Products
ARTANELederle LaboratoriesN-006773 DISCN1982-01-01
4 products
ARTANELederle LaboratoriesN-012947 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
trihexyphenidyl hydrochlorideANDA2023-05-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
drug-induced abnormalities—D000014—
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04A: Anticholinergic agents
— N04AA: Tertiary amines, anticholinergic
— N04AA01: Trihexyphenidyl
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRIHEXYPHENIDYL
INNtrihexyphenidyl
Description
Trihexyphenidyl, also known as benzhexol and trihex, is an antiparkinsonian agent of the antimuscarinic class. It was approved by the FDA for the treatment of Parkinson's in 2003.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1
Identifiers
PDB—
CAS-ID144-11-6
RxCUI10811
ChEMBL IDCHEMBL1490
ChEBI ID9720
PubChem CID5572
DrugBankDB00376
UNII ID6RC5V8B7PO (ChemIDplus, GSRS)
Target
Agency Approved
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM1
Gene synonyms
NCBI Gene ID
1128
Protein name
muscarinic acetylcholine receptor M1
Protein synonyms
acetylcholine receptor, muscarinic 1
Uniprot ID
Q96RH1
Mouse ortholog
Chrm1 (12669)
muscarinic acetylcholine receptor M1 (Q8BJN3)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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