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Trimetrexate glucuronate
Neutrexin (trimetrexate glucuronate) is a small molecule pharmaceutical. Trimetrexate glucuronate was first approved as Neutrexin on 1993-12-17. It is used to treat pneumocystis pneumonia in the USA. It is known to target dihydrofolate reductase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trimetrexate glucuronate
Tradename
Company
Number
Date
Products
NEUTREXINMedImmuneN-020326 DISCN1993-12-17
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pneumocystis pneumoniaEFO_0007448D011020B59
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01A: Agents against amoebiasis and other protozoal diseases
— P01AX: Other agents against amoebiasis and other protozoal diseases in atc
— P01AX07: Trimetrexate
HCPCS
Code
Description
J3305
Injection, trimetrexate glucuronate, per 25 mg
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—1———1
AdenocarcinomaD000230—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRIMETREXATE GLUCURONATE
INNtrimetrexate
Description
Trimetrexate is a member of quinazolines. It has a role as an antifungal drug.
Classification
Small molecule
Drug classantimetabolites (folic acid derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC.O=C(O)[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
Identifiers
PDB—
CAS-ID52128-35-5
RxCUI42333
ChEMBL IDCHEMBL2218878
ChEBI ID—
PubChem CID5583
DrugBankDB01157
UNII IDUPN4ITI8T4 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DHFR
DHFR
Organism
Homo sapiens
Gene name
DHFR
Gene synonyms
NCBI Gene ID
1719
Protein name
dihydrofolate reductase
Protein synonyms
Uniprot ID
Q6IRW8
Mouse ortholog
Dhfr (13361)
dihydrofolate reductase (Q61579)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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