Skip to content
Triprolidine
Actahist, Actidil, Actifed, Allerfed, Corphed, Histafed, Myfed, Myidyl, Trilitron, Triphed (triprolidine) is a small molecule pharmaceutical. Triprolidine was first approved as Triprolidine hydrochloride on 1982-01-01. It is used to treat allergic conjunctivitis, atopic dermatitis, and rhinitis in the USA. The pharmaceutical is active against histamine H1 receptor.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
eye diseasesD005128
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Codeine phosphate
+
Pseudoephedrine hydrochloride
+
Triprolidine hydrochloride
Tradename
Company
Number
Date
Products
ACTIFED W/ CODEINEGSKN-012575 DISCN1984-04-04
1 products
Hide discontinued
Pseudoephedrine hydrochloride
+
Triprolidine hydrochloride
Tradename
Company
Number
Date
Products
ACTIFEDGSKN-018996 DISCN1985-06-17
1 products
Hide discontinued
Triprolidine hydrochloride
Tradename
Company
Number
Date
Products
ACTIDILGSKN-011110 DISCN1983-07-01
1 products
ACTIDILGSKN-011496 DISCN1983-07-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
corphedraNew Drug Application2019-12-05
mucinex fast-max day severe congestion and cough and mucinex nightshift night cold and fluOTC monograph final2023-06-08
triacin-cANDA2015-07-28
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic conjunctivitisEFO_0007141D003233H10.44
atopic dermatitisEFO_0000274D003876L20
rhinitisEFO_0008521D012220J31
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AX: Other antihistamines for systemic use in atc
— R06AX07: Triprolidine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameTRIPROLIDINE
INNtriprolidine
Description
Triprolidine is an N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It is a N-alkylpyrrolidine, a member of pyridines and an olefinic compound. It is a conjugate base of a triprolidine(1+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1
Identifiers
PDB—
CAS-ID486-12-4
RxCUI10849
ChEMBL IDCHEMBL855
ChEBI ID84116
PubChem CID5282443
DrugBankDB00427
UNII ID2L8T9S52QM (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 686 documents
View more details
Safety
Black-box Warning
Black-box warning for: Triacin-c
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
10 adverse events reported
View more details