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Tromethamine
Osmoprep, Phosphates (tromethamine) is a small molecule pharmaceutical. Tromethamine was first approved as Sodium phosphates in plastic container on 1983-05-10. It is used to treat acidosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Combinations
Osmoprep, Phosphates (generic drugs available since 2011-12-30, discontinued: Visicol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium phosphate
+
dibasic
+
anhydrous
+
Sodium phosphate
+
monobasic
+
monohydrate
Tradename
Company
Number
Date
Products
OSMOPREPSalix PharmaceuticalsN-021892 RX2006-03-16
1 products, RLD, RS
Show 1 discontinued
Sodium phosphate
+
dibasic
+
heptahydrate
+
Sodium phosphate
+
monobasic
+
anhydrous
Tradename
Company
Number
Date
Products
SODIUM PHOSPHATES IN PLASTIC CONTAINERHospiraN-018892 RX1983-05-10
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
carboprost tromethamineANDA2023-06-20
osmoprepNew Drug Application2019-03-04
potassium phosphatesunapproved drug other2022-07-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acidosisEFO_1000014D000138E87.2
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Sodium Phosphate, Dibasic, Anhydrous / Sodium Phosphate, Monobasic, Monohydrate, Osmoprep, Salix Pharms
76870752028-06-22DS, DP
ATC Codes
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05B: Iv solutions used in parenteral administration of fluids, electrolytes and nutrients
— B05BB: Solutions affecting the electrolyte balance
— B05BB03: Trometamol
— B05X: I.v. solution additives
— B05XX: Other i.v. solution additives in atc
— B05XX02: Trometamol
HCPCS
Code
Description
J1885
Injection, ketorolac tromethamine, per 15 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTROMETHAMINE
INNtrometamol
Description
Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac trometamol".
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NC(CO)(CO)CO
Identifiers
PDB—
CAS-ID77-86-1
RxCUI10865
ChEMBL IDCHEMBL1200391
ChEBI ID9754
PubChem CID6503
DrugBankDB03754
UNII ID023C2WHX2V (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 90,338 documents
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Safety
Black-box Warning
Black-box warning for: Osmoprep
Adverse Events
Top Adverse Reactions
Mock data
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9 adverse events reported
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