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Tropicamide
Mydcombi, Mydriacyl, Mydriafair, Paremyd (tropicamide) is a small molecule pharmaceutical. Tropicamide was first approved as Mydriacyl on 1982-01-01. It is used to treat iridocyclitis, iritis, and keratitis in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M5.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Combinations
Mydcombi (discontinued: Paremyd)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydroxyamphetamine hydrobromide
+
Tropicamide
Tradename
Company
Number
Date
Products
PAREMYDAkornN-019261 DISCN1992-01-30
1 products, RLD
Hide discontinued
Phenylephrine hydrochloride
+
Tropicamide
Tradename
Company
Number
Date
Products
MYDCOMBIEyenoviaN-215352 RX2023-05-05
1 products, RLD, RS
Tropicamide
Tradename
Company
Number
Date
Products
MYDRIACYLAlcon ResearchN-012111 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
mydcombiNew Drug Application2023-05-09
mydriacyl ANDA2023-02-15
paremydNew Drug Application2022-02-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
iridocyclitisHP_0001094D015863H20
iritisEFO_1000997D007500—
keratitis—D007634H16
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA06: Tropicamide
— S01FA56: Tropicamide, combinations
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinopathy of prematurityD012178EFO_1001158H35.1———3—3
MydriasisD015878HP_0011499H57.04——21—3
Intraocular pressureD0074291——1—2
MyopiaD009216H52.1———112
CataractD002386EFO_0001059H26.9———112
Corneal transplantationD016039EFO_0010676———1—1
Refractive errorsD012030EFO_0003908H52.7———1—1
AnisocoriaD015875H57.02———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Premature birthD047928EFO_0003917O60——1——1
Eye diseasesD005128EFO_0003966H44——1——1
Type 2 diabetes mellitusD003924EFO_0001360E11——1——1
Type 1 diabetes mellitusD003922EFO_0001359E10——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PresbyopiaD011305H52.4—1———1
SialorrheaD012798HP_0002307K11.7—1———1
Parkinson diseaseD010300EFO_0002508G20—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low visionD015354————11
Fabry diseaseD000795E75.21————11
Retinal detachmentD012163EFO_0005773H33.2————11
Macular degenerationD008268EFO_0001365H35.30————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTROPICAMIDE
INNtropicamide
Description
Tropicamide is a member of acetamides.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
Identifiers
PDB—
CAS-ID1508-75-4
RxCUI10869
ChEMBL IDCHEMBL1200604
ChEBI ID—
PubChem CID5593
DrugBankDB00809
UNII IDN0A3Z5XTC6 (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
CHRM2
CHRM2
CHRM4
CHRM4
CHRM5
CHRM5
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,700 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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30,182 adverse events reported
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