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Ubenimex
Ubenimex is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target leukotriene A-4 hydrolase and cytosol aminopeptidase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pulmonary arterial hypertensionD000081029—2———2
LymphedemaD008209Q82.0—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameUBENIMEX
INNubenimex
Description
Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia and lymphedema. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.
Classification
Small molecule
Drug classimmunostimulants
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O
Identifiers
PDB—
CAS-ID58970-76-6
RxCUI—
ChEMBL IDCHEMBL29292
ChEBI ID—
PubChem CID72172
DrugBankDB03424
UNII IDI0J33N5627 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
LTA4H
LTA4H
LAP3
LAP3
Organism
Homo sapiens
Gene name
LTA4H
Gene synonyms
LTA4
NCBI Gene ID
4048
Protein name
leukotriene A-4 hydrolase
Protein synonyms
Leukotriene A(4) hydrolase, LTA-4 hydrolase, testicular secretory protein Li 27, Tripeptide aminopeptidase LTA4H
Uniprot ID
Q9UCT7
Mouse ortholog
Lta4h (16993)
leukotriene A-4 hydrolase (P24527)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 366 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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