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Valemetostat
Valemetostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone-lysine N-methyltransferase EZH1 and histone-lysine N-methyltransferase EZH2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Adult t-cell leukemia-lymphomaD015459C91.5—2———2
B-cell lymphomaD016393—1———1
LymphomaD008223C85.911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C611————1
Renal cell carcinomaD0022921————1
Castration-resistant prostatic neoplasmsD0641291————1
Urologic neoplasmsD014571C64-C681————1
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVALEMETOSTAT
INNvalemetostat
Description
Valemetostat (trade name Ezharmia) is a drug used for the treatment of adult T-cell leukemia/lymphoma (ATL).
Classification
Small molecule
Drug classenzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(C)c(CNC(=O)c2cc(Cl)c3c(c2C)O[C@@](C)([C@H]2CC[C@H](N(C)C)CC2)O3)c(=O)[nH]1
Identifiers
PDB—
CAS-ID1809336-39-7
RxCUI—
ChEMBL IDCHEMBL4597193
ChEBI ID—
PubChem CID126481870
DrugBank—
UNII ID60RD0234VE (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
EZH1
EZH1
EZH2
EZH2
Organism
Homo sapiens
Gene name
EZH1
Gene synonyms
KIAA0388
NCBI Gene ID
2145
Protein name
histone-lysine N-methyltransferase EZH1
Protein synonyms
Enhancer of zeste homolog 1, ENX-2
Uniprot ID
Q92800
Mouse ortholog
Ezh1 (14055)
histone-lysine N-methyltransferase EZH1 (Q9R089)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 71 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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