Valoctocogene roxaparvovec
Roctavian (valoctocogene roxaparvovec) is a gene pharmaceutical. Valoctocogene roxaparvovec was first approved as Roctavian on 2022-08-24.
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | 3 | 3 | 3 | — | — | 6 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Genetic therapy | D015316 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VALOCTOCOGENE ROXAPARVOVEC |
| INN | valoctocogene roxaparvovec |
| Description | Valoctocogene roxaparvovec, sold under the brand name Roctavian, is a gene therapy for the treatment of hemophilia A. It was developed by BioMarin Pharmaceutical. Valoctocogene roxaparvovec is made of a virus (AAV5) that has been modified to contain the gene for factor VIII, which is lacking in patients with haemophilia A. It is given by intravenous infusion.
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| Classification | Gene |
| Drug class | Antihemorrhagics |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1819334-78-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297579 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15561 |
| UNII ID | 681K1JDI8M (ChemIDplus, GSRS) |
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