Venglustat
Venglustat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target ceramide glucosyltransferase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fabry disease | D000795 | E75.21 | — | 2 | 2 | — | — | 4 | |
| Gaucher disease | D005776 | Orphanet_355 | E75.22 | — | 1 | 1 | — | — | 2 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VENGLUSTAT |
| INN | venglustat |
| Description | Venglustat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target ceramide glucosyltransferase. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: glucosyltransferase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2ccc(F)cc2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1401090-53-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297611 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | BLP1XA3FZA (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
UGCG
UGCG
Organism
Homo sapiens
Gene name
UGCG
Gene synonyms
NCBI Gene ID
Protein name
ceramide glucosyltransferase
Protein synonyms
GCS, GLCT-1, Glucosylceramide synthase, Glycosylceramide synthase, UDP-glucose ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase
Uniprot ID
Mouse ortholog
Ugcg (22234)
ceramide glucosyltransferase (O88693)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 156 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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