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Verubecestat
Verubecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against beta-secretase 1. In addition, it is known to target beta-secretase 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03312——5
AmnesiaD000647EFO_1001454F44.01—1——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVERUBECESTAT
INNverubecestat
Description
Verubecestat (MK-8931) was an experimental drug for the treatment of Alzheimer's disease. It is an inhibitor of beta-secretase 1 (BACE1), which, after initial promise proved disappointing.
Classification
Small molecule
Drug classenzyme inhibitors: beta secretase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O
Identifiers
PDB—
CAS-ID1286770-55-5
RxCUI—
ChEMBL IDCHEMBL3301601
ChEBI ID—
PubChem CID51352361
DrugBankDB12285
UNII IDJ1I0P6WT7T (ChemIDplus, GSRS)
Target
Agency Approved
BACE1
BACE1
Organism
Homo sapiens
Gene name
BACE1
Gene synonyms
BACE, KIAA1149
NCBI Gene ID
23621
Protein name
beta-secretase 1
Protein synonyms
APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2
Uniprot ID
P56817
Mouse ortholog
Bace1 (23821)
beta-secretase 1 (P56818)
Alternate
BACE2
BACE2
Organism
Homo sapiens
Gene name
BACE2
Gene synonyms
AEPLC, ALP56, ASP21
NCBI Gene ID
25825
Protein name
beta-secretase 2
Protein synonyms
56 kDa aspartic-like protease, Asp 1, ASP1, Aspartic-like protease 56 kDa, Aspartyl protease 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, Down region aspartic protease, Down syndrome region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, SLCO3A1/BACE2 fusion, Theta-secretase, transmembrane aspartic proteinase Asp1
Uniprot ID
Q9Y5Z0
Mouse ortholog
Bace2 (56175)
beta-secretase 2 (Q9JL18)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 561 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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