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Vinblastine
Velban (vinblastine) is a small molecule pharmaceutical. Vinblastine was first approved as Velban on 1982-01-01. It is used to treat breast neoplasms, choriocarcinoma, head and neck neoplasms, histiocytosis, and hodgkin disease amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
respiratory tract diseasesD012140
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vinblastine sulfate
Tradename
Company
Number
Date
Products
VELBANEli LillyN-012665 DISCN1982-01-01
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
vinblastine sulfate ANDA2019-12-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
choriocarcinoma—D002822C58
head and neck neoplasms—D006258—
histiocytosisHP_0100727D015614—
hodgkin disease—D006689C81
kaposi sarcoma—D012514C46
kidney neoplasmsEFO_0003865D007680C64
lung neoplasms—D008175C34.90
mycosis fungoides—D009182C84.0
testicular neoplasms—D013736C62
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CA: Vinca alkaloids and analogues, antineoplastic
— L01CA01: Vinblastine
HCPCS
Code
Description
J9360
Injection, vinblastine sulfate, 1 mg
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Major depressive disorderD003865EFO_0003761F22—276—15
Post-traumatic stress disordersD013313EFO_0001358F43.1—1—1—2
MorbidityD009017———1—1
AnxietyD001007EFO_0005230F41.1———1—1
Separation anxietyD001010EFO_1001916———1—1
DepressionD003863F33.9———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Anxiety disordersD001008EFO_0006788F41.1——2——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Marijuana abuseD002189EFO_0007191F12—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9————11
Social phobiaD000072861EFO_1001917F40.1————11
Hot flashesD019584————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVINBLASTINE
INNvinblastine
Description
Vincaleukoblastine is a vinca alkaloid, an indole alkaloid fundamental parent, a methyl ester, an acetate ester, a tertiary alcohol, a tertiary amino compound, an organic heterotetracyclic compound and an organic heteropentacyclic compound. It has a role as a microtubule-destabilising agent, an antineoplastic agent, a plant metabolite and an immunosuppressive agent.
Classification
Small molecule
Drug classantihistaminics (histamine-H1 receptor antagonists); vinca alkaloids
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1
Identifiers
PDB—
CAS-ID865-21-4
RxCUI11198
ChEMBL IDCHEMBL159
ChEBI ID—
PubChem CID241903
DrugBankDB00570
UNII ID5V9KLZ54CY (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
P07437
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 22,027 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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5,650 adverse events reported
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