Xylometazoline
Xylometazoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target alpha-1D adrenergic receptor.
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Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| metarivin soln. 0.1% | unapproved drug other | 2022-09-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| nasal obstruction | HP_0001742 | D015508 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AA: Sympathomimetics, plain
— R01AA07: Xylometazoline
— R01AB: Sympathomimetics, combinations excl. corticosteroids
— R01AB06: Xylometazoline
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01G: Decongestants and antiallergics
— S01GA: Sympathomimetics used as decongestants
— S01GA03: Xylometazoline
— S01GA53: Xylometazoline, combinations
HCPCS
No data
Clinical
Clinical Trials
65 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 3 | 2 | 5 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | — | — | 1 | 1 | 2 |
| Nasal obstruction | D015508 | HP_0001742 | — | — | — | 1 | 1 | 2 | |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | 1 | 1 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | 1 | — | 1 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | — | — | 1 | — | 1 |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | 1 | — | 1 | |
| Epistaxis | D004844 | EFO_0003895 | R04.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | 1 | 2 | 1 | — | — | 3 | ||
| Common cold | D003139 | EFO_0007214 | J00 | — | — | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 4 | — | — | — | 4 |
| Prostatic neoplasms | D011471 | C61 | — | 2 | — | — | — | 2 | |
| Non-small-cell lung carcinoma | D002289 | 1 | 2 | — | — | — | 2 | ||
| Stable angina | D060050 | I20.8 | — | 2 | — | — | — | 2 | |
| Sarcoma | D012509 | — | 1 | — | — | — | 1 | ||
| Vascular dementia | D015140 | F01 | — | 1 | — | — | — | 1 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Colonic neoplasms | D003110 | C18 | — | 1 | — | — | — | 1 | |
| Rectal neoplasms | D012004 | — | 1 | — | — | — | 1 | ||
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 6 | — | — | — | — | 6 | |
| Lung neoplasms | D008175 | C34.90 | 1 | — | — | — | — | 1 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Low back pain | D017116 | HP_0003419 | M54.5 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | C92.0 | 1 | — | — | — | — | 1 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | — | — | — | — | 1 | |
| Myeloid leukemia chronic-phase | D015466 | 1 | — | — | — | — | 1 | ||
| Myeloproliferative disorders | D009196 | D47.1 | 1 | — | — | — | — | 1 | |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | C95 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gingival recession | D005889 | K06.0 | — | — | — | — | 2 | 2 | |
| Bronchoscopy | D001999 | — | — | — | — | 1 | 1 | ||
| Healthy volunteers/patients | — | — | — | — | — | 1 | 1 | ||
| Bronchiolitis | D001988 | HP_0011950 | — | — | — | — | 1 | 1 | |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 1 | 1 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | — | — | — | 1 | 1 |
| Social phobia | D000072861 | EFO_1001917 | F40.1 | — | — | — | — | 1 | 1 |
| Autism spectrum disorder | D000067877 | F84.0 | — | — | — | — | 1 | 1 | |
| Cognitive behavioral therapy | D015928 | — | — | — | — | 1 | 1 | ||
| Wounds and injuries | D014947 | T14.8 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | XYLOMETAZOLINE |
| INN | xylometazoline |
| Description | Xylometazoline is an alkylbenzene. |
| Classification | Small molecule |
| Drug class | antihistamines/local vasoconstrictors (antazoline type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1 |
Identifiers
| PDB | — |
| CAS-ID | 526-36-3 |
| RxCUI | 39841 |
| ChEMBL ID | CHEMBL312448 |
| ChEBI ID | 10082 |
| PubChem CID | 5709 |
| DrugBank | DB06694 |
| UNII ID | WPY40FTH8K (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 719 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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296 adverse events reported
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