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Zosuquidar
Zosuquidar is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target ATP-dependent translocase ABCB1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C95——1——1
Myelodysplastic syndromesD009190D46——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemiaD007951C9222———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZOSUQUIDAR
INNzosuquidar
Description
Zosuquidar (development code LY-335979) is an experimental antineoplastic drug. Zosquidir inhibits P-glycoproteins. Other drugs with this mechanism include tariquidar and laniquidar. P-glycoproteins are trans-membrane proteins that pump foreign substances out of cells in an ATP dependent fashion. Cancers overexpressing P-glycoproteins are able to pump out therapeutic molecules before they are able to reach their target, effectively making the cancer multi-drug resistant. Zosuquidar inhibits P-glycoproteins, inhibiting the efflux pump and restoring sensitivity to chemotherapeutic agents.
Classification
Small molecule
Drug classmultidrug resistance inhibitors: quinoline derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O[C@@H](COc1cccc2ncccc12)CN1CCN([C@@H]2c3ccccc3[C@@H]3[C@H](c4ccccc42)C3(F)F)CC1
Identifiers
PDB—
CAS-ID167354-41-8
RxCUI—
ChEMBL IDCHEMBL444172
ChEBI ID—
PubChem CID153997
DrugBankDB06191
UNII IDAB5K82X98Y (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ABCB1
ABCB1
Organism
Homo sapiens
Gene name
ABCB1
Gene synonyms
MDR1, PGY1
NCBI Gene ID
5243
Protein name
ATP-dependent translocase ABCB1
Protein synonyms
ATP-binding cassette sub-family B member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, CD243, colchicin sensitivity, doxorubicin resistance, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1
Uniprot ID
Q14812
Mouse ortholog
Abcb1b (18669)
ATP-dependent translocase ABCB1 (P06795)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 644 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8 adverse events reported
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